Cell-membrane-inspired polymers for constructing biointerfaces with efficient molecular recognition

Ishihara, Kazuhíko; Fukazawa, Kyoko

doi:10.1039/d2tb00242f

Cited by 9 publications

(4 citation statements)

References 262 publications

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“…Various cell surface-modifying materials and strategies, such as polycations, LBL, and encapsulation via hydrogel developed over the past decade, have shown a tendency to interfere with the intrinsic function of cells. , However, polycations can interact excessively with negatively charged cellular membranes, resulting in high cytotoxicity. For instance, when cells were treated with 100 μg/mL poly- l -lysin (PLL), only 10% of cells survived and random adherence of PLL to the cell surface was observed .…”

Section: Resultsmentioning

confidence: 99%

Biomaterial-Mediated Exogenous Facile Coating of Natural Killer Cells for Enhancing Anticancer Efficacy toward Hepatocellular Carcinoma

Jangid,

Kim,

Kim

et al. 2023

Bioconjugate Chem.

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Natural killer (NK) cells exhibit a good therapeutic efficacy against various malignant cancer cells. However, the therapeutic efficacy of plain NK cells is relatively low due to inadequate selectivity for cancer cells. Therefore, to enhance the targeting selectivity and anticancer efficacy of NK cells, we have rationally designed a biomaterial-mediated ex vivo surface engineering technique for the membrane decoration of cancer recognition ligands onto NK cells. Our designed lipid conjugate biomaterial contains three major functional moieties: (1) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) lipid for cell membrane anchoring, (2) polyethylene glycol for intracellular penetration blocker, and (3) lactobionic acid (LBA) for cancer recognition. The biomaterial was successfully applied to NK cell surfaces (LBA-NK) to enhance recognition and anticancer functionalities, especially toward asialoglycoprotein receptor (ASGPR)-overexpressing hepatocellular carcinoma. Highly efficient and homogeneous NK cell surface editing was achieved with a simple coating process while maintaining intrinsic properties of NK cells. LBA-NK cells showed potential ASGPR-mediated tumor cell binding (through LBA-ASGPR interaction) and thereby significantly augmented anticancer efficacies against HepG2 liver cancer cells. Thus, LBA-NK cells can be a novel engineering strategy for the treatment of liver cancers via facilitated immune synapse interactions in comparison with currently available cell therapies.

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Section: Resultsmentioning

confidence: 99%

Biomaterial-Mediated Exogenous Facile Coating of Natural Killer Cells for Enhancing Anticancer Efficacy toward Hepatocellular Carcinoma

Jangid,

Kim,

Kim

et al. 2023

Bioconjugate Chem.

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“…Surface-initiated living radical polymerization has been studied to clarify the molecular structure and to cover the surface with a polymer brush layer. − , In this method, an initiator for living radical polymerization is bound to the surface of a base material and a monomer is polymerized from this functional group. In living polymerization, the initiation reaction is a rate-determining process; the growth reaction rate is low, and there is no termination reaction.…”

Section: Biomimetic Design Of Silicone Hydrogel Contact Lensesmentioning

confidence: 99%

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Ishihara,

Shi,

Fukazawa

et al. 2023

ACS Appl. Bio Mater.

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Contact lenses are one of the most successful applications of biomaterials. The chemical structure of the polymers used in contact lenses plays an important role in determining the function of contact lenses. Different types of contact lenses have been developed based on the chemical structure of polymers. When designing contact lenses, materials scientists consider factors such as mechanical properties, processing properties, optical properties, histocompatibility, and antifouling properties, to ensure long-term wear with minimal discomfort. Advances in contact lens materials have addressed traditional issues such as oxygen permeability and biocompatibility, improving overall comfort, and duration of use. For example, silicone hydrogel contact lenses with high oxygen permeability were developed to extend the duration of use. In addition, controlling the surface properties of contact lenses in direct contact with the cornea tissue through surface polymer modification mimics the surface morphology of corneal tissue while maintaining the essential properties of the contact lens, a significant improvement for long-term use and reuse of contact lenses. This review presents the material science elements required for advanced contact lenses of the future and summarizes the chemical methods for achieving these goals.

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“…Molecular recognition is a key in functional systems such as molecular machines and molecular sensors [ 126 , 127 , 128 ]. Related research has been widely conducted.…”

Section: From Recent Examplesmentioning

confidence: 99%

Molecular Machines and Microrobots: Nanoarchitectonics Developments and On-Water Performances

Ariga

2022

Micromachines

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This review will focus on micromachines and microrobots, which are objects at the micro-level with similar machine functions, as well as nano-level objects such as molecular machines and nanomachines. The paper will initially review recent examples of molecular machines and microrobots that are not limited to interfaces, noting the diversity of their functions. Next, examples of molecular machines and micromachines/micro-robots functioning at the air-water interface will be discussed. The behaviors of molecular machines are influenced significantly by the specific characteristics of the air-water interface. By placing molecular machines at the air-water interface, the scientific horizon and depth of molecular machine research will increase dramatically. On the other hand, for microrobotics, more practical and advanced systems have been reported, such as the development of microrobots and microswimmers for environmental remediations and biomedical applications. The research currently being conducted on the surface of water may provide significant basic knowledge for future practical uses of molecular machines and microrobots.

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Cell-membrane-inspired polymers for constructing biointerfaces with efficient molecular recognition

Abstract: Fabrication of devices that accurately recognize, detect, and separate target molecules from mixtures is a crucial aspect of biotechnology for applications in medical, pharmaceutical, and food sciences. This technology has...

Cited by 9 publications

References 262 publications

Biomaterial-Mediated Exogenous Facile Coating of Natural Killer Cells for Enhancing Anticancer Efficacy toward Hepatocellular Carcinoma

Biomaterial-Mediated Exogenous Facile Coating of Natural Killer Cells for Enhancing Anticancer Efficacy toward Hepatocellular Carcinoma

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Molecular Machines and Microrobots: Nanoarchitectonics Developments and On-Water Performances

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