Cell Membrane Coated pH-Responsive Intelligent Bionic Delivery Nanoplatform for Active Targeting in Photothermal Therapy

Abstract

Aim To produce pH-responsive bionic high photothermal conversion nanoparticles actively targeting tumors for sensitizing photothermal therapy (PTT). Materials and Methods The bionic nanoparticles (ICG-PEI@HM NPs) were prepared by electrostatic adsorption of indocyanine green (ICG) coupled to polyethyleneimine (PEI) and modified with tumor cell membranes. In vitro and in vivo experiments were conducted to investigate the efficacy of ICG-PEI@HM-mediated PTT. Results The intelligent responsiveness of ICG-PEI@HM to pH promoted the accumulation of ICG and enhanced the PTT performance of ICG-PEI@HM NPs. Compared with free ICG, NPs exhibited great photothermal stability, cellular uptake, and active tumor targeting for PTT. Conclusion ICG-PEI@HM NPs can enhance the efficacy of PTT and can be used as a new strategy for the construction of photothermal agents.

Near-Infrared Light-Triggered NO Nanogenerator for Gas-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy to Eliminate Biofilms

“…Notably, Li et al and Zhang et al reported that PEI and PEG have no significant UV absorption peaks. 35,36 A red shift was observed at 700-800 nm for SNP/PEI-ICG@PEG, which could be attributed to the strong binding of ICG within the polymer core. The presence of an absorption peak near 808 nm for SNP/PEI-ICG@PEG confirmed its potential for both PTT and PDT upon laser excitation at this wavelength.…”

Near Infrared-Activatable Biomimetic Nanoplatform for Tumor-Specific Drug Release, Penetration and Chemo-Photothermal Synergistic Therapy of Orthotopic Glioblastoma

“… 38–40 Thus, the developed drug delivery system achieves dual-targeting of glioblastomas and brain vascular endothelial cells. Upon reaching the tumor site and subsequent exposure to 808 nm laser irradiation, ICG induces effective hyperthermia, 41 , 42 facilitating localized thermal therapy and triggering the burst release of SN38. The released SN38, by inhibiting DNA topoisomerase, induces tumor cells apoptosis, thereby realizing the synergistic effects of chemo-photothermal therapy.…”