Cell-mediated immunity induced in mice after vaccination with a protease activation mutant, TR-2, of Sendai virus

Tashiro, Masato; Fujii, Yoichi; Nakamura, Kenzo; Homma, M.

doi:10.1128/jvi.62.7.2490-2497.1988

Cited by 10 publications

(2 citation statements)

References 54 publications

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“…In addition, a maximum murine CTL response to Sendai virus was observed at about 12 p.i. (27). In contrast, maximum direct CTL responses in horses against equine herpesvirus were detected by 2 and 3 weeks p.i.…”

Section: Discussionmentioning

confidence: 82%

Specific cytotoxic T lymphocytes are involved in in vivo clearance of infectious bronchitis virus

Seo

Collisson

1997

J Virol

110

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Cytotoxic T-lymphocyte (CTL) responses to infectious bronchitis virus (IBV) were determined at regular intervals between 3 and 30 days postinfection (p.i.). The maximum response with 82% lysis of labeled target cells was detected at 10 days p.i. The specific CTL response did not begin to decline until the amount of virus, which peaked at day 8 p.i. in both the kidneys and lungs, started to decrease. Clinical respiratory signs of illness also correlated with amount of virus. CTL activity was shown to be major histocompatibility complex (MHC) class restricted because the lysis of MHC-mismatched targets was negligible, and lysis was mediated by CD8 ؉ CD4 ؊ T cells, as the CTL response could be abolished with removal of CD8 ؉ CD4 ؊ but not CD4 ؉ CD8 ؊ lymphocytes. In contrast, immunoglobulin M (IgM) antibody was not detected until day 10 p.i., and levels peaked at day 12 p.i.; IgG antibody levels were minimal until day 15 p.i. but continued to increase exponentially until day 30 p.i., the last day examined. In summary, CTL responses correlated with initial decreases in infection and illness.

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Section: Discussionmentioning

confidence: 82%

Specific cytotoxic T lymphocytes are involved in in vivo clearance of infectious bronchitis virus

Seo

Collisson

1997

J Virol

110

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“…Sendai virus, a member of the family paramyxoviridae, is a common causative agent for pneumonia in mice and often causes outbreaks of the disease in laboratory mice (11). To protect mice from Sendai virus infection, several experiments including our own vaccination experiment using a trypsin-resistant mutant have been conducted (2,3,10,26,42,43,47). However, detailed mechanism of the protection is yet to be elucidated.…”

mentioning

confidence: 99%

Protection of Mice against Sendai Virus Pneumonia by Non‐Neutralizing Anti‐F Monoclonal Antibodies

Mochizuki

Ming

Hayashi

et al. 1990

Microbiology and Immunology

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Role of Specific Cell-Mediated Cytotoxicity in Protecting Fish from Viral Infections

2002

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We report the in vivo role of specific cytotoxic cells in protecting fish from acute viral infections. Specifically, we found that (1) there is an inverse relationship between cytotoxic activities and viral load and (2) adoptive transfer of immune leukocytes prevented viral infection. Crucian carp hematopoietic necrosis virus (CHNV), which has a virulence to ginbuna crucian carp, was recently found and identified in Japan. Specific cell-mediated cytotoxicity of ginbuna leukocytes against CHNV-infected syngeneic cells was induced as a result of intraperitoneal inoculation with CHNV. This cytotoxicity was not induced against either virus-infected allogeneic cells or eel rhabidovirus- (EVA) infected syngeneic cells. In these respects, the cytotoxic activity was similar to that of mammalian cytotoxic T-lymphocyte (CTL) activity. Viral titers of tissues from infected fish were remarkably reduced 8 days after infections, when specific cytotoxic activity reached a peak. This result suggested that specific cytotoxic cells were responsible for the early control of CHNV replication. On the other hand, CHNV-specific antibody was greatly increased when the virus was eliminated by cytotoxic activities. The effectiveness of the virus-specific cytotoxicity was evaluated using adoptive cell transfer. Recipients that received leukocytes from immune syngeneic donors escaped CHNV infection. These findings suggest that virus-specific cytotoxic cells have a role in controlling viral infections in a fish.

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Cell-mediated immunity induced in mice after vaccination with a protease activation mutant, TR-2, of Sendai virus

Cited by 10 publications

References 54 publications

Specific cytotoxic T lymphocytes are involved in in vivo clearance of infectious bronchitis virus

Specific cytotoxic T lymphocytes are involved in in vivo clearance of infectious bronchitis virus

Protection of Mice against Sendai Virus Pneumonia by Non‐Neutralizing Anti‐F Monoclonal Antibodies

Role of Specific Cell-Mediated Cytotoxicity in Protecting Fish from Viral Infections

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