Cell mechanics in biomedical cavitation

Wang, Qianxi; Manmi, Kawa; Liu, Kuo-Kang

doi:10.1098/rsfs.2015.0018

Cited by 21 publications

(13 citation statements)

References 92 publications

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“…Li and coworkers formulated nanodiamonds loaded with both ATRA and DOX for the treatment of both liver and breast cancers. Under ultrasound effect, these DDSs were able to trigger the reversible opening of tumor endothelial tight junctions by sonoporation and cavitation mechanisms [180,181]. Furthermore, in order to increase the drug retention in the tumor site, nanodiamonds were employed as nanocarriers due to their capability to bypass the drug efflux mechanisms [182].…”

Section: Stimuli-responsivenessmentioning

confidence: 99%

Current Trends in ATRA Delivery for Cancer Therapy

et al. 2020

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All-Trans Retinoic Acid (ATRA) is the most active metabolite of vitamin A. It is critically involved in the regulation of multiple processes, such as cell differentiation and apoptosis, by activating specific genomic pathways or by influencing key signaling proteins. Furthermore, mounting evidence highlights the anti-tumor activity of this compound. Notably, oral administration of ATRA is the first choice treatment in Acute Promyelocytic Leukemia (APL) in adults and NeuroBlastoma (NB) in children. Regrettably, the promising results obtained for these diseases have not been translated yet into the clinics for solid tumors. This is mainly due to ATRA-resistance developed by cancer cells and to ineffective delivery and targeting. This up-to-date review deals with recent studies on different ATRA-loaded Drug Delivery Systems (DDSs) development and application on several tumor models. Moreover, patents, pre-clinical, and clinical studies are also reviewed. To sum up, the main aim of this in-depth review is to provide a detailed overview of the several attempts which have been made in the recent years to ameliorate ATRA delivery and targeting in cancer.

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Section: Stimuli-responsivenessmentioning

confidence: 99%

Current Trends in ATRA Delivery for Cancer Therapy

et al. 2020

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“…The suppression of secular terms on the right-hand side of (18) now requires that the righthand sides of (26) and (27) have zero average over a single cycle of oscillation.…”

Section: The First Correctionmentioning

confidence: 99%

“…Microbubble dynamics are associated with important applications such as the cavitation damage to pumps, turbines and propellers 1,4,[18][19][20][21] . Ultrasound-driven microbubbles are widely used in biomedical technology [22][23][24][25][26] , sonochemistry 27 and ultrasonic cavitation cleaning 28 .…”

Section: Introductionmentioning

confidence: 99%

Viscous decay of nonlinear oscillations of a spherical bubble at large Reynolds number

Smith

Wang

2017

Physics of Fluids

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Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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“…Microbubble dynamics are associated cavitation damage to pumps, turbines and propellers Lauterborn & Kurz 2010), as well as applications in biomedical ultrasonics (Coussios & Roy 2007;Curtiss et al 2013;Wang et al 2015b;Vyas et al 2016Vyas et al , 2017, sonochemistry (Suslick 1990;Blake 1999) and cavitation cleaning (Ohl et al 2006;Reuter et a. 2017).…”

Section: Introductionmentioning

confidence: 99%

Microbubble dynamics in a viscous compressible liquid near a rigid boundary

Qianxi

Liu

Leppinen

et al. 2019

IMA Journal of Applied Mathematics

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This paper is concerned with microbubble dynamics in a viscous compressible liquid near a rigid boundary. The compressible effects are modelled using the weakly compressible theory of Wang & Blake (2010, Non-spherical bubble dynamics in a compressible liquid. Part 1. Travelling acoustic wave. J. Fluid Mech., 730, 245–272), since the Mach number associated is small. The viscous effects are approximated using the viscous potential flow theory of Joseph & Wang (2004, The dissipation approximation and viscous potential flow. J. Fluid Mech., 505, 365–377), because the flow field is characterized as being an irrotational flow in the bulk volume but with a thin viscous boundary layer at the bubble surface. Consequently, the phenomenon is modelled using the boundary integral method, in which the compressible and viscous effects are incorporated into the model through including corresponding additional terms in the far field condition and the dynamic boundary condition at the bubble surface, respectively. The numerical results are shown in good agreement with the Keller–Miksis equation, experiments and computations based on the Navier–Stokes equations. The bubble oscillation, topological transform, jet development and penetration through the bubble and the energy of the bubble system are simulated and analysed in terms of the compressible and viscous effects.

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Cell mechanics in biomedical cavitation

Cited by 21 publications

References 92 publications

Current Trends in ATRA Delivery for Cancer Therapy

Current Trends in ATRA Delivery for Cancer Therapy

Viscous decay of nonlinear oscillations of a spherical bubble at large Reynolds number

Microbubble dynamics in a viscous compressible liquid near a rigid boundary

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