Cell lineage of the subcommissural organ secretory ependymocytes: Differentiating role of the environment

Didier-Bazes, M.; Chouaf-Lakhdar, Latifa; Dutuit, Magali; Aguera, M.; Belin, Marie‐Françoise

doi:10.1002/1097-0029(20010301)52:5<461::aid-jemt1032>3.0.co;2-h

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Our study included the SCO, considered a CVO in spite of its lack of fenestrated vessels. We show that the SCO displays vimentin‐positive elongated cells as described in the literature (Chouaf et al, ; Didier‐Bazes et al, ). These cells display apical long cytoplasm forming the ventricular wall (Meiniel, ) and basal processes extending into brain parenchyma and for a few of them projecting to BBB capillaries (Rodriguez et al, ).…”

Section: Discussionsupporting

confidence: 87%

Tanycyte‐like cells form a blood–cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

Langlet

Mullier

Bouret

et al. 2013

J of Comparative Neurology

227

156

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Tanycytes are highly specialized ependymal cells that form a blood–cerebrospinal fluid (CSF) barrier at the level of the median eminence (ME), a circumventricular organ (CVO) located in the tuberal region of the hypothalamus. This ependymal layer harbors well-organized tight junctions, a hallmark of central nervous system barriers that is lacking in the fenestrated portal vessels of the ME. The displacement of barrier properties from the vascular to the ventricular side allows the diffusion of blood-borne molecules into the parenchyma of the ME while tanycyte tight junctions control their diffusion into the CSF, thus maintaining brain homeostasis. In the present work, we combined immunohistochemical and permeability studies to investigate the presence of tanycyte barriers along the ventricular walls of other brain CVOs. Our data indicate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs possess long processes that project into the parenchyma of the CVOs to reach the fenestrated capillary network. Remarkably, these tanycyte-like cells display well-organized tight junctions around their cell bodies. Consistent with these observations, permeability studies show that this ependymal layer acts as a diffusion barrier. Together, our results suggest that tanycytes are a characteristic feature of all CVOs and yield potential new insights into their involvement in regulating the exchange between the blood, the brain, and the CSF within these “brain windows.”

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Section: Discussionsupporting

confidence: 87%

Tanycyte‐like cells form a blood–cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

Langlet

Mullier

Bouret

et al. 2013

J of Comparative Neurology

227

156

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“…Ependimócitos são as células revestem os ventrículos cerebrais e o canal central da medula espinhal, envolvidos no processo de produção e circulação do líquido cerebrospinal (DIDIER-BAZÈS et al, 2001).…”

Section: Células Do Sistema Nervosounclassified

Componentes Celulares Do Sistema Nervoso: Uma Revisão Narrativa De Literatura

De Souza Campos,

Agrela Rodrigues,

Ramos Zamora Gudayo

et al. 2023

Ciencia Latina

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Introdução: O sistema nervoso é um sistema complexo e vital que controla e coordena todas as atividades do corpo. Ele permite a comunicação rápida entre diferentes órgãos e sistemas, permitindo respostas rápidas a estímulos internos e externos. Objetivo: Compreender mediante revisão bibliográfica as estruturas e funções dos componentes que integram o sistema nervoso. Metodologia: o estudo atual consiste em uma revisão narrativa de literatura sobre os elementos celulares que compõem o sistema nervoso. Resultados e conclusão: O sistema nervoso é vital para o corpo humano, supervisionando desde funções fundamentais, como respiração e batimentos cardíacos, até processos mentais como pensamentos e emoções. Sua importância se reflete na regulação do corpo e na capacidade de se ajustar ao ambiente.

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“…In addition to tanycytes, ependymocytes were labelled with YFP expression, indicating they express nestin. Interestingly, nestin expression in ependymocytes has not been clearly described [Bruni, 1998;Didier-Bazès et al, 2001;Jiménez et al, 2014], and the few instances of reported nestin expression are circumstantial due to the lack of absolute distinction between, or specific labelling of ependymocytes versus tanycytes or subependymal astrocytes [Chouaf-Lakdar et al, 2003;Coskun et al, 2008;Chojnacki et al, 2009;Hendrickson et al, 2011]. However, our observation of positive YFP expression to be clearly demonstrated in the hypothalamus, these cells may likely express nestin (since their cellular equivalent in the SVZ; B1 cells do [Doetsch et al, 1997]) and thus may also be labelled in our transgenic fate-mapping model.…”

Section: Ependymocytesmentioning

confidence: 79%

Mechanisms regulating adult neurogenesis in the hypothalamus using a genetic inducible-approach to label and optogenetically stimulate hypothalamic neural progenitors

Peswani¹

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Chapter 1: Review of adult neurogenesis in the hypothalamus 1 Historical overview of adult neurogenesis 1 The canonical neurogenic niches 3 Emerging sites of adult neurogenesis 8 Structure and functions of the hypothalamus 9 Adult hypothalamic neurogenesis Initial studies Cell proliferation in the adult hypothalamus Chapter 4: Optogenetic stimulation of nestin-expressing cells induced an increase in newly-generated cells near tanycytes Background Purinergic signalling in Tanycytes Purinergic signalling in neural stem/progenitor cells Using optogenetics to stimulate intracellular calcium waves and ATP release Aims Methods Animals In vitro validation In vivo opto-stimulation experiment Results ChR2-YFP expression in NCE-ChR2Y mice is not exclusively restricted to tanycytes In vitro validation In vivo characterization and experiments Discussion Optogenetic stimulation in acute brain slices induced calcium responses in tanycytes reminiscent of those elicited by ATP Optogenetic stimulation of tanycytes could induce downstream signalling in parenchymal cells Tanycytes represent the majority of opto-responsive hypothalamic cells, albeit non-specific ChR2 expression Short-term in vivo optogenetic stimulation of nestinexpressing hypothalamic cells Long-term in vivo optogenetic stimulation of nestinexpressing hypothalamic cells Summary General summary of discussion Regulation of adult hypothalamic neurogenesis by extrinsic stimuli Genetic labelling of putative hypothalamic neural stem/ progenitor cells Optogenetic stimulation of putative hypothalamic neural stem/progenitor cells Concluding remarks References vii Abbreviations 3V 3 rd ventricle 4-OHT 4-hydroxy tamoxifen

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Cell lineage of the subcommissural organ secretory ependymocytes: Differentiating role of the environment

Cited by 3 publications

References 38 publications

Tanycyte‐like cells form a blood–cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

Tanycyte‐like cells form a blood–cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

Componentes Celulares Do Sistema Nervoso: Uma Revisão Narrativa De Literatura

Mechanisms regulating adult neurogenesis in the hypothalamus using a genetic inducible-approach to label and optogenetically stimulate hypothalamic neural progenitors

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