Cell Line Specific Radiosensitizing Effect of Zalcitabine (2',3'-dideoxycytidine)

Coucke, Philippe; Li, Yexiong; Copaceanu, Marie-Laure; Paschoud, Nicolas; Cottin, E; Ozşahin, Mahmut; Mirimanoff, R.O.

doi:10.3109/02841869709109230

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…Moreover, ddC has also been noted to have sensitising effects with ionizing radiation. Indeed, Coucke et al (128) showed a dosedependent response of ddC treatment to sensitization with radiation. This is of particular interest since radiotherapy generates reactive oxygen species (ROS) in vivo, including the aggressively-reactive hydroxy radical (…”

Section: Targeting the Mitochondria As A Translational Therapeutic Apmentioning

confidence: 99%

The importance of mitochondria in the tumourigenic phenotype: Gliomas as the paradigm (Review)

Liang¹

2011

Int J Mol Med

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Abstract. Cancer arises from the accumulation of nuclear and cytoplasmic abnormalities, a phenomenon allowing for the expression of the tumourigenic phenotype. Gliomas represent the most frequently diagnosed tumours of the central nervous system in adults. Warburg hypothesized the importance of glycolysis in cancer cells, and implicated additional roles of mitochondria in neoplasia. Recent data have shown the importance of mitochondria in the tumourigenic phenotype, in particular, within the apoptotic process. There have been a variety of studies conducted on brain tumours revealing significant alterations of mitochondria within the tumourigenic phenotype. This review describes some of the more recent findings of mitochondria and gliomas, correlating findings to those observed in other cancers. Alterations in mitochondrial DNA copy number and location, as well as dependence of the cancer cell phenotype on mitochondria are emphasised. In addition to its role in apoptosis, the mitochondrion serves as an important element in the tumourigenic phenotype, and clinical approaches targeting this organelle have potential for the development of effective treatment regimens for patients with glioma and other neoplastic diseases.

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Section: Targeting the Mitochondria As A Translational Therapeutic Apmentioning

confidence: 99%

The importance of mitochondria in the tumourigenic phenotype: Gliomas as the paradigm (Review)

Liang¹

2011

Int J Mol Med

View full text Add to dashboard Cite

show abstract

Cell Line Specific Radiosensitizing Effect of Zalcitabine (2',3'-dideoxycytidine)

Cited by 1 publication

References 25 publications

The importance of mitochondria in the tumourigenic phenotype: Gliomas as the paradigm (Review)

The importance of mitochondria in the tumourigenic phenotype: Gliomas as the paradigm (Review)

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