Cell line cytotoxicity, antiadipogenic and glucose uptake activity of Sarcostemma brevistigma Wight. &amp; Arn.

Krishnamoorthy, Vijayalakshmi; Selvaraj, Chinnadurai Immanuel

doi:10.1007/s11033-018-4423-1

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Cytotoxicity was determined by the MTT method, a colorimetric test that evaluates the enzymatic reduction of this compound in formazan salts, performed by metabolically active cell dehydrogenases and then considered viable (Vijayalakshmi & Selvaraj, 2018). Tests with free EE indicated a dose‐dependent effect, with reduced cell viability, adipocytes 3T3‐L1 cells, accompanied by an increase in extract concentration.…”

Section: Resultsmentioning

confidence: 99%

Spray drying encapsulation of stevia extract with maltodextrin and evaluation of the physicochemical and functional properties of produced powders

Zorzenon

Formigoni

Silva

et al. 2020

Journal of Food Science

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This work aimed to formulate and perform physicochemical and functional characterization of maltodextrin microcapsules containing ethanolic extract of stevia, rich in antioxidant compounds, encapsulated by a spray-drying process with two maltodextrins (DE10 and DE19). The powders were named M10 and M19, respectively. We analyzed the physicochemical parameters, antidiabetic activity, cytotoxicity, bioaccessibility of the compounds by in vitro digestion, as well as the structure of the microcapsules by scanning electron microscopy. Microcapsules showed higher solubility (∼35%), lower moisture content (∼29%), and the maltodextrin DE10 had higher efficiency as an encapsulating agent (87%) when compared to DE19 (76%) and showed well-defined spherical structures. The microencapsulation preserved the content of phenolic compounds and antioxidant activity present in the extract (7.2% and 87.5%, respectively). The bioaccessibility of these microencapsulated compounds and antioxidant activity were higher under different conditions of in vitro digestion (mouth, gastric, and intestinal conditions) and showed no cytotoxic effects. We identified 41 compounds (by UHPLC-MS/MS-Qtof) related to the nutritional benefits offered by stevia and the microencapsulation technique can be recommended to preserve bioactive compounds.

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Section: Resultsmentioning

confidence: 99%

Spray drying encapsulation of stevia extract with maltodextrin and evaluation of the physicochemical and functional properties of produced powders

Zorzenon

Formigoni

Silva

et al. 2020

Journal of Food Science

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“…The EtBl, in particular, show a significant ability to entrap glucose, and it was delivered to slow the passage of glucose into the external solution compared to the control at 180 minutes. The existence of insoluble fibre molecules that trap glucose molecules could explain why the ethyl acetate portion inhibited glucose transit the most 63 . A simple method of determining the effect of EtBl and other extracts to retard glucose diffusion through the normal dialysis membrane, the dialysis tube method relies on the EtBl and other extracts, which, in the intestinal tract, aids glucose transportation, thanks to glucose transporters that are integrated with other molecules and the assistance of intestinal contractions 64 .…”

Section: Glucose Diffusion Inhibitory Activitymentioning

confidence: 99%

Secondary Metabolites Screening, in Vitro Antioxidant and Antidiabetic Activity of Marine Red Alga Botryocladia Leptopoda (J.Agardh) Kylin

P¹,

p²

2022

Orient. J. Chem

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Today, seaweed has become essential to medicine due to its ability to treat disease-afflicted cells without majorly influencing healthy cells and tissues. This study included a phytochemical analysis, in vitro antioxidant and antidiabetic activity of all the extracts of Botryocladia leptopoda. Also, analyse the cytotoxicity and glucose absorption activity of the ethanolic extract of B. leptopoda using 3T3 cell line through MTT assay. The extraction of secondary metabolites from B. leptopoda using various solvents (hexane, chloroform, ethyl acetate, ethanol and water) resulted in alkaloids, Phenol and Flavonoids. The ethanolic extract of B. leptopoda showed the best in vitro antioxidant and antidiabetic activity compared with all the experimented extracts. Ethanolic extract exhibited no cytotoxicity and improved glucose absorption. This study has revealed that marine red alga B. leptopoda showed noticeable in vitro antioxidant, antidiabetic activities and no toxic effect toward normal cells. We suggested to carry out the antidiabetic activity through in vivo investigations on Botryocladia leptopoda (J.Agardh) Kylin.

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Glucose uptake: A promising target of medicinal plants

Akdad,

Eddouks

2024

Antidiabetic Medicinal Plants

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Cell line cytotoxicity, antiadipogenic and glucose uptake activity of Sarcostemma brevistigma Wight. & Arn.

Cited by 4 publications

References 23 publications

Spray drying encapsulation of stevia extract with maltodextrin and evaluation of the physicochemical and functional properties of produced powders

Spray drying encapsulation of stevia extract with maltodextrin and evaluation of the physicochemical and functional properties of produced powders

Secondary Metabolites Screening, in Vitro Antioxidant and Antidiabetic Activity of Marine Red Alga Botryocladia Leptopoda (J.Agardh) Kylin

Glucose uptake: A promising target of medicinal plants

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