Cell-Graph Compass: Modeling Single Cells with Graph Structure Foundation Model
Chen Fang,
Zhilong Hu,
Shaole Chang
et al.
Abstract:Inspired by the advancements in pre-trained Large Language Models, there has been a surge of studies in the Life Sciences focusing on constructing foundation models with large scale single-cell RNA-seq data. These studies typically involve pre-training a transformer model on large-scale single-cell sequencing data, followed by fine-tuning for a variety of downstream tasks, achieving notable performance. However, these models all share a common short-coming: to utilize the transformer architecture, originally d… Show more
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