Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes

Liu, Guanqi; Zhou, Xuan; Zhang, Linjun; Yang, Ziqiang; Xue, Junlong; Xia, Ruidi; Abuduxiku, Nuerbiya; Gan, Xuejing; Liu, Runheng; Chen, Zhuofan; Yang, Cao; Chen, Zetao

doi:10.1016/j.mtbio.2022.100432

Cited by 6 publications

(3 citation statements)

References 67 publications

(83 reference statements)

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“…To some extent, the hydrogel scaffolds can only initiate the local immune response rather than systemic immunity. As a result, biomaterials' degradation product sometimes induces immunomodulation (adaptive immunity) and is later excised from the body via urine [ [323] , [324] , [325] ]. Similarly, nanoparticle-based immunotherapeutic have similar issues with long-term dynamic immunomodulation.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Dutta

Ganguly

Patil

et al. 2023

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Dutta

Ganguly

Patil

et al. 2023

Bioactive Materials

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“…However, some cells cannot multiply; therefore, the injured tissue is replaced by connective scar tissue. In healing, growth factors such as FGF-α and β, TGF-β and platelet-derived growth factor (PDGF), which stimulate the synthesis of matrix compounds, as well as their deposition at the injured site, stand out in importance [ 11 , 19 , 20 , 21 ].…”

Section: Inflammatory Process: An Overviewmentioning

confidence: 99%

Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review

et al. 2023

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Curcumin (CUR) is a polyphenol extracted from the rhizome of Curcuma longa that possesses potent anti-inflammatory and antioxidant potential. Despite CUR’s numerous beneficial effects on human health, it has limitations, such as poor absorption. Nano-based drug delivery systems have recently been applied to improve CUR’s solubility and bioavailability and potentialize its health effects. This review investigated the effects of different CUR-based nanomedicines on inflammatory and immunomodulated diseases. PUBMED, EMBASE, COCHRANE, and GOOGLE SCHOLAR databases were searched, and the Scale for Assessment of Narrative Review Articles (SANRA) was used for quality assessment and PRISMA guidelines. Overall, 66 studies were included comprising atherosclerosis, rheumatoid arthritis (RA), Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), Huntington’s disease (HD), inflammatory bowel diseases (IBD), psoriasis, liver fibrosis, epilepsy, and COVID-19. The available scientific studies show that there are many known nanoformulations with curcumin. They can be found in nanosuspensions, nanoparticles, nanoemulsions, solid lipid particles, nanocapsules, nanospheres, and liposomes. These formulations can improve CUR bioavailability and can effectively be used as adjuvants in several inflammatory and immune-mediated diseases such as atheroma plaque formation, RA, dementia, AD, PD, MS, IBD, psoriasis, epilepsy, COVID-19, and can be used as potent anti-fibrotic adjuvants in fibrotic liver disease.

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“…[ 1 ] The primary treatment goals involve mitigating inflammation and fostering the regeneration of functional periodontal tissues, with AB reconstruction being a pivotal step in this process. [ 2 ] In clinical practice, GBR is an effective approach for reconstructing AB. This technique involves the application of a barrier film, known as a GBR film, to impede the rapid growth of gingival connective tissue and thwart its invasion into bone defects.…”

Section: Introductionmentioning

confidence: 99%

Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment

Lei,

Wan,

Song

et al. 2024

Advanced Science

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Currently available guided bone regeneration (GBR) films lack active immunomodulation and sufficient osteogenic ability‐ in the treatment of periodontitis, leading to unsatisfactory treatment outcomes. Challenges remain in developing simple, rapid, and programmable manufacturing methods for constructing bioactive GBR films with tailored biofunctional compositions and microstructures. Herein, the controlled electroassembly of collagen under the salt effect is reported, which enables the construction of porous films with precisely tunable porous structures (i.e., porosity and pore size). In particular, bioactive salt species such as the anti‐inflammatory drug diclofenac sodium (DS) can induce and customize porous structures while enabling the loading of bioactive salts and their gradual release. Sequential electro‐assembly under pre‐programmed salt conditions enables the manufacture of a Janus composite film with a dense and DS‐containing porous layer capable of multiple functions in periodontitis treatment, which provides mechanical support, guides fibrous tissue growth, and acts as a barrier preventing its penetration into bone defects. The DS‐containing porous layer delivers dual bio‐signals through its morphology and the released DS, inhibiting inflammation and promoting osteogenesis. Overall, this study demonstrates the potential of electrofabrication as a customized manufacturing platform for the programmable assembly of collagen for tailored functions to adapt to specific needs in regenerative medicine.

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Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes

Cited by 6 publications

References 67 publications

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review

Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment

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