Cell-Free Amniotic Fluid and Regenerative Medicine: Current Applications and Future Opportunities

Bowen, Charles M.; Ditmars, Frederick S.; Gupta, Ashim; Reems, Jo‐Anna; Fagg, W. Samuel

doi:10.3390/biomedicines10112960

Cited by 3 publications

(1 citation statement)

References 99 publications

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“…65 Cell-free amnionic fluid derivatives have also proven effective in not only cases of corneal wound healing but also for symptoms of keratoconjunctivitis sicca. 66 Another approach is to place a few drops of these solutions into an ocular surface drug depot system such as Hyper-CL™ (EyeYon Medical, Ness Ziona, Israel). This theoretically protects the ocular surface from the mechanical action of blinking and increases the ocular surface contact time with the solution.…”

Section: Methods For Pre-op Ocular Surface Optimizationmentioning

confidence: 99%

Solving STODS - Surgical Temporary Ocular Discomfort Syndrome

Hirabayashi¹,

Barnett²

2022

Preprint

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The term STODS (Surgical Temporary Ocular Discomfort Syndrome) has been coined to describe the ocular surface perturbations induced by surgery. As one of the most important refractive elements of the eye, Guided Ocular Surface and Lid Disease (GOLD) optimization is fundamental to success in achieving refractive outcomes and mitigating STODS. Effective GOLD optimization and the prevention/treatment of STODS, requires an understanding of the molecular, cellular and anatomic factors that influence ocular surface microenviroment and the associated perturbations induced by surgical intervention. By reviewing the current understanding of STODS etiologies, we will attempt to outline a rationale for a tailored GOLD optimization depending on the ocular surgical insult. With a bench to bedside approach, we will highlight clinical examples of effective GOLD perioperative optimization can mitigate STODS deleterious effect on preoperative imaging and postoperative healing.

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Section: Methods For Pre-op Ocular Surface Optimizationmentioning

confidence: 99%

Solving STODS - Surgical Temporary Ocular Discomfort Syndrome

Hirabayashi¹,

Barnett²

2022

Preprint

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Use of amniotic membrane in hard-to-heal wounds: a multicentre retrospective study

Ditmars,

Kay,

Broderick

et al. 2024

J Wound Care

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Objective: Hard-to-heal (chronic) wounds negatively impact patients and are a source of significant strain on the healthcare system and economy. These wounds are often resistant to standard of care (SoC) wound healing approaches due to a diversity of underlying pathologies. Cellular, acellular, and matrix-like products, such as amniotic membranes (AM), are a potential solution to these challenges. A growing body of evidence suggests that AM may be useful for treatment-resistant wounds; however, limited information is available regarding the efficacy of dehydrated amniotic membrane (DHAM) on multi-aetiology, hard-to-heal wounds. Therefore, we analysed the efficacy of DHAM treatment in reducing the size of hard-to-heal diabetic and venous leg ulcers (VLUs) that had failed to improve after SoC-based treatments. Method: In this multicentre retrospective study, we analysed wound size during clinic visits for patients being treated for either diabetic or VLUs. During each visit, the treatment consisted of debridement followed by application of DHAM. Each wound was measured after debridement and prior to DHAM application, and wound volumes over time or number of DHAM applications were compared. Results: A total of 18 wounds in 11 patients were analysed as part of this study. Wounds showed a significant reduction in volume after a single DHAM application, and a 50% reduction in wound size was observed after approximately two DHAM applications. These findings are consistent with reports investigating DHAM treatment of diabetic ulcers that were not necessarily resistant to treatment. Conclusion: To our knowledge, this study is the first to directly compare the efficacy of standalone DHAM application to hard-to-heal diabetic and venous leg ulcers, and our findings indicate that DHAM is an effective intervention for resolving these types of wounds. This suggests that implementing this approach could lead to fewer clinic visits, cost savings and improved patient quality of life. Declaration of interest: This research was supported in part by Merakris Therapeutics, US, and facilitated access to deidentified patient datasets, which may represent a perceived conflict of interest; however, the primary data analysis was performed by FSB who is unaffiliated with Merakris Therapeutics. TCB is a founder, employee of and shareholder in Merakris Therapeutics; WSF is a co-founder of, consultant for, and shareholder in Merakris Therapeutics, and was also supported by the National Institutes of Health National Center for Advancing Translational Sciences Clinical and Translational Science Awards Grant KL2 Scholars Program (KL2TR001441). The research was also supported through endowments to WSF from the University of Texas Medical Branch Mimmie and Hallie Smith Endowed Chair of Transplant Research and the John L Hern University Chair in Transplant Surgery.

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Solving STODS—Surgical Temporary Ocular Discomfort Syndrome

Hirabayashi

Barnett²

2023

Diagnostics

View full text Add to dashboard Cite

The term STODS (Surgical Temporary Ocular Discomfort Syndrome) has been coined to describe the ocular surface perturbations induced by surgery. As one of the most important refractive elements of the eye, Guided Ocular Surface and Lid Disease (GOLD) optimization is fundamental to success in achieving refractive outcomes and mitigating STODS. Effective GOLD optimization and the prevention/treatment of STODS requires an understanding of the molecular, cellular, and anatomic factors that influence ocular surface microenvironment and the associated perturbations induced by surgical intervention. By reviewing the current understanding of STODS etiologies, we will attempt to outline a rationale for a tailored GOLD optimization depending on the ocular surgical insult. With a bench-to-bedside approach, we will highlight clinical examples of effective GOLD perioperative optimization that can mitigate STODS’ deleterious effect on preoperative imaging and postoperative healing.

show abstract

Cell-Free Amniotic Fluid and Regenerative Medicine: Current Applications and Future Opportunities

Cited by 3 publications

References 99 publications

Solving STODS - Surgical Temporary Ocular Discomfort Syndrome

Solving STODS - Surgical Temporary Ocular Discomfort Syndrome

Use of amniotic membrane in hard-to-heal wounds: a multicentre retrospective study

Solving STODS—Surgical Temporary Ocular Discomfort Syndrome

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