Cell fate determination and Hippo signaling pathway in preimplantation mouse embryo

Yildirim, Ecem; Bora, Gizem; Onel, Tugce; Talas, Nilsu; Yaba, Aylin

doi:10.1007/s00441-021-03530-8

Cited by 11 publications

(6 citation statements)

References 207 publications

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“…It was observed that before the 8-cell embryo polarization, ezrin was uniformly distributed over the entire cell surface. Once ezrin was phosphorylated, it aggregated from the cell junctions to the apical region, causing the microvilli to also aggregate in the apical region, indicating that phosphorylation of ezrin threonine-567 is necessary for the redistribution of embryo polarization ( Yildirim et al, 2021 ; Zhang et al, 2022b ). Recent studies have revealed that transcription factor AP-2 gamma (Tfap2c) and TEA domain transcription factor 4 (Tead4) can recruit ezrin proteins to localize to the membrane and promote the polarized growth of apical protein clusters, which eventually leads to apical protein centration.…”

Section: The Biological Function Of Ezrin In the Female Reproductive ...mentioning

confidence: 99%

Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications

Shi²,

Xu³

et al. 2023

Front. Cell Dev. Biol.

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Ezrin, a plasma membrane-microfilament linker, is a cytoskeletal organizer involved in many cellular activities by binding to the membrane protein-ezrin-cytoskeletal protein complex and regulating downstream signal transduction. Increasing evidence demonstrates that ezrin plays an important role in regulating cell polarity, proliferation and invasion. In this study, we analyzed the effects of ezrin on oocytes, follicle development, embryo development and embryo implantation. We reviewed the recent studies on the modalities of ezrin regulation and its involvement in the biological processes of female reproductive physiology and summarized the current research advances in ezrin inhibitors. These studies will provide new strategies and insights for the treatment of diseases.

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Section: The Biological Function Of Ezrin In the Female Reproductive ...mentioning

confidence: 99%

Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications

Shi²,

Xu³

et al. 2023

Front. Cell Dev. Biol.

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“…Daughter cells demonstrating a lower tensile force remain outside and adopt a wedge shape. Although the junction length between constricting cells and their The transition from inner/outer cells to pluripotent ICM/TE lineages is achieved through the control of the Hippo signaling pathway and its effects on lineage-specific gene expressions (46). For TE specification, Caudal-related homeobox 2 transcription factor (Cdx2) expression along with POU-family transcription factor Oct3/4 and Nanog repression is required.…”

Section: Triggering Radial Polarization By Inducing Par Asymmetry Via...mentioning

confidence: 99%

Overview of junctional complexes during mammalian early embryonic development

2023

Self Cite

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Cell-cell junctions form strong intercellular connections and mediate communication between blastomeres during preimplantation embryonic development and thus are crucial for cell integrity, polarity, cell fate specification and morphogenesis. Together with cell adhesion molecules and cytoskeletal elements, intercellular junctions orchestrate mechanotransduction, morphokinetics and signaling networks during the development of early embryos. This review focuses on the structure, organization, function and expressional pattern of the cell–cell junction complexes during early embryonic development. Understanding the importance of dynamic junction formation and maturation processes will shed light on the molecular mechanism behind developmental abnormalities of early embryos during the preimplantation period.

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“…Subsequently, ICM can give rise to primitive endoderm (PE) and epiblast (EPI) during the second cell lineage decision. PE marked by GATA6 and SOX17 would develop into extra-embryonic tissues and EPI marked by NANOG would contribute to the embryo proper ( Zhu & Zernicka-Goetz 2020 , Yildirim et al 2021 ). Understanding the molecular machinery of lineage specification is important for proper embryonic development and stem cell derivation.…”

Section: Introductionmentioning

confidence: 99%

Functional role of GATA3 and CDX2 in lineage specification during bovine early embryonic development

Shi

Wang

et al. 2023

Reproduction

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Current understandings of the initiation of the trophectoderm (TE) program during mammalian embryonic development lack evidence of how TE-associated factors such as GATA3 and CDX2 participate in bovine lineage specification. In this study, we describe effects of TE-associated factors on the expression of lineage specification marker genes such as SOX2, OCT4, NANOG, GATA6 and SOX17, by using cytosine base editor system. We successfully knockout GATA3 or CDX2 in bovine embryos with robust efficiency. However, GATA3 or CDX2 deletion does not affect the developmental potential of embryos to reach blastocyst stage. Interestingly, GATA3 deletion downregulates the NANOG expression in bovine blastocysts. Further analysis of the mosaic embryos shows that GATA3 is required for NANOG in the TE of bovine blastocysts. Single blastocyst RNA-seq analysis reveals that GATA3 deletion disrupts the transcriptome in bovine blastocysts. Altogether, we propose that GATA3 plays an important role in maintaining TE lineage program in bovine embryos and the functional role of GATA3 is species-specific.

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Cell fate determination and Hippo signaling pathway in preimplantation mouse embryo

Cited by 11 publications

References 207 publications

Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications

Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications

Overview of junctional complexes during mammalian early embryonic development

Functional role of GATA3 and CDX2 in lineage specification during bovine early embryonic development

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