Cell encapsulation via microtechnologies

Kang, Ah Ran; Park, Ji Soo; Ju, Jongil; Jeong, Gi Seok; Lee, Sang Hoon

doi:10.1016/j.biomaterials.2013.12.073

Cited by 211 publications

(166 citation statements)

References 138 publications

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“…In addition, when the formed MCSs encapsulated inside the hydrogel droplets are injected into the patient's body, they are protected from host immune responses, which minimizes administration of immunosuppressive drugs and increases the successful transplantation rate [125]. This approach also has a high degree of control over the morphological and physical properties [109].…”

Section: Micro-droplets-based Multicellular Spheroid Formationmentioning

confidence: 99%

“…The micro-moulding method has been explored to generate MSCs by fabricating complex structures using the lithography technique [109,110]. It has been documented that this micro moulding method can significantly reduce consumption of reagents, create desired concentration gradients of growth/signal factors and nutrients, allow high-density culture at a high cell-to-fluid volume ratio and decrease shear stress under the laminar condition in micro-scale structures [111].…”

Section: Micro-mouldingmentioning

confidence: 99%

See 1 more Smart Citation

Advances in multicellular spheroids formation

Cui¹,

Hartanto²,

Zhang³

2017

J. R. Soc. Interface.

394

336

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Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure, dynamic cell -cell/cell -matrix interactions and bio-mimicking in vivo microenvironment. As a fundamental building block for tissue reconstruction, MCSs have emerged as a powerful tool to narrow down the gap between the in vitro and in vivo model. In this review paper, we discussed the structure and biology of MCSs and detailed fabricating methods. Among these methods, the approach in microfluidics with hydrogel support for MCS formation is promising because it allows essential cell -cell/cell -matrix interactions in a confined space.

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Section: Micro-droplets-based Multicellular Spheroid Formationmentioning

confidence: 99%

Section: Micro-mouldingmentioning

confidence: 99%

Advances in multicellular spheroids formation

Cui¹,

Hartanto²,

Zhang³

2017

J. R. Soc. Interface.

394

336

View full text Add to dashboard Cite

show abstract

“…This is sheared by the oil (continuous) flow. As a result of the immiscible nature of water and oil, droplets are formed (7, 47). Rapid exchange of the toxic oil phase in a microencapsulation chip is critical to maintaining a high cell survival rate (55).…”

Section: Bioencapsulation Materials and Methodsmentioning

confidence: 99%

Bioencapsulation Technologies in Tissue Engineering

Majewski

Zhang

et al. 2016

Journal of Applied Biomaterials & Functional Materials

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Bioencapsulation technologies have played an important role in the developing successes of tissue engineering. Besides offering immunoisolation, they also show promise for cell/tissue banking and the directed differentiation of stem cells, by providing a unique microenvironment. This review describes bioencapsulation technologies and summarizes their recent progress in research into tissue engineering. The review concludes with a brief outlook regarding future research directions in this field.

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“…The PDMS chip used to prepare the fibers was constructed by aligning and bonding two concave hemicylindrical PDMS channels using oxygen plasma treatment (Kang et al, 2010(Kang et al, , 2011. This PDMS chip was used to continuously prepare monodisperse microfibers for cell encapsulation and tissue engineering (Kang et al, 2012(Kang et al, , 2014Jun et al, 2013Jun et al, , 2014a.…”

Section: Spinning Via a Tapered Duct-based Elongational Mechanismmentioning

confidence: 99%

Development of New Smart Materials and Spinning Systems Inspired by Natural Silks and Their Applications

Cheng

Lee

2016

Front. Mater.

Self Cite

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Silks produced by spiders and silkworms are charming natural biological materials with highly optimized hierarchical structures and outstanding physicomechanical properties. The superior performance of silks relies on the integration of a unique protein sequence, a distinctive spinning process, and complex hierarchical structures. Silks have been prepared to form a variety of morphologies and are widely used in diverse applications, for example, in the textile industry, as drug delivery vehicles, and as tissue engineering scaffolds. This review presents an overview of the organization of natural silks, in which chemical and physical functions are optimized, as well as a range of new materials inspired by the desire to mimic natural silk structure and synthesis.

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Cell encapsulation via microtechnologies

Cited by 211 publications

References 138 publications

Advances in multicellular spheroids formation

Advances in multicellular spheroids formation

Bioencapsulation Technologies in Tissue Engineering

Development of New Smart Materials and Spinning Systems Inspired by Natural Silks and Their Applications

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