2022
DOI: 10.1088/2057-1976/ac4e2d
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Cell encapsulation in alginate-based microgels using droplet microfluidics; a review on gelation methods and applications

Abstract: Cell encapsulation within the microspheres using a semi-permeable polymer allows the two-way transfer of molecules such as oxygen, nutrients, and growth factors. The main advantages of cell encapsulation technology include controlling the problems involved in transplanting rejection in tissue engineering applications and reducing the long-term need for immunosuppressive drugs following organ transplantation to eliminate the side effects. Cell-laden microgels can also be used in 3D cell cultures, wound healing,… Show more

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Cited by 20 publications
(12 citation statements)
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“…Among all the biomaterials used in this approach, hydrogel-based scaffolds have shown great potential for easy cell encapsulation with biocompatibility and biomimetic of ECM properties, as they can mimic the 3D cell environment of natural tissues. The hydrogel-based scaffold should induce changes in cell functions to regulate cell fate (proliferation, migration, and differentiation) by withstanding biomechanical loads and allowing nutrient transport [67,68]. To design a hydrogel scaffold that delivers biomechanical stimulation to cells, it is important to study its polymer species and their properties and stimulation approaches.…”
Section: D Culture Microenvironment In Cell-encapsulated Hydrogelsmentioning
confidence: 99%
“…Among all the biomaterials used in this approach, hydrogel-based scaffolds have shown great potential for easy cell encapsulation with biocompatibility and biomimetic of ECM properties, as they can mimic the 3D cell environment of natural tissues. The hydrogel-based scaffold should induce changes in cell functions to regulate cell fate (proliferation, migration, and differentiation) by withstanding biomechanical loads and allowing nutrient transport [67,68]. To design a hydrogel scaffold that delivers biomechanical stimulation to cells, it is important to study its polymer species and their properties and stimulation approaches.…”
Section: D Culture Microenvironment In Cell-encapsulated Hydrogelsmentioning
confidence: 99%
“…In the literature, natural tissue conjugates such as organ or tissue decellularized matrices or collagen, gelatin, Matrigel, alginate have been suggested as ideal structures for scaffold based 3D culture [68][69][70][71][72][73][74][75][76]. The autologous cell derived extracellular matrix developed within the scope of this study can be also a good resource that would be used as an alternative to these materials or in combination with them.…”
Section: Resultsmentioning
confidence: 99%
“…Alginate can encapsulate cells, is easily crosslinked, and can be chemically modified for additional crosslinking capabilities. [48,50] It is most often extracted from brown algae and then further processed to obtain alginic acid, but alginate can also be biosynthesized by some species of Azotobacter as well as Pseudomonas. [48] Carrageenans are polysaccharides extracted from red algae of the class Rhodophyceae.…”
Section: Natural Bioinksmentioning
confidence: 99%