Cell Division: Interkinetic Nuclear… Mechanics

Cammarota, Christian; Bergstralh, Daniel T.

doi:10.1016/j.cub.2020.05.028

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…In pseudostratified epithelia, nuclei must migrate to the apical surface to undergo mitosis. The mechanistic basis of this requirement is unclear, 17,20,29 but it is considered to be an essential feature of cell-cycle progression in pseudostratified epithelia (assumption A1). In accordance with previous findings, 21,22,25,[30][31][32] we assume that the apical-ward movement of G2 nuclei is an active process, probably driven by actomyosin.…”

Section: Modeling Interkinetic Nuclear Migrationmentioning

confidence: 99%

Mechanical constraints to cell-cycle progression in a pseudostratified epithelium

et al. 2022

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Section: Modeling Interkinetic Nuclear Migrationmentioning

confidence: 99%

Mechanical constraints to cell-cycle progression in a pseudostratified epithelium

et al. 2022

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“…IKNM are characteristic of many epithelia (46)(47)(48), hence our conclusions might be relevant to other tissues besides the neural tube. Our analysis indicated that IKNMs exert their effect on cell rearrangements by affecting the apical surface area kinetics of cells.…”

Section: Discussionmentioning

confidence: 79%

Cell cycle dynamics controls fluidity of the developing mouse neuroepithelium

Bocanegra-Moreno

Singh

Hannezo

et al. 2022

Preprint

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As organs are remodelled by morphogenetic changes and pattern formation during development, their material properties may change. To address whether and how this occurs in the mouse neural tube, we combined highly resolved mosaic analysis, biophysical modelling and perturbation experiments. We found that at early developmental stages the neuroepithelium surprisingly maintains both high junctional tension and high fluidity. This is achieved via a previously unrecognized mechanism in which interkinetic nuclear movements generate cell area dynamics that drive extensive cell rearrangements. Over time, the proliferation rate declines, effectively solidifying the tissue. Thus, unlike well-studied jamming transitions, the solidification we uncovered resembles a glass transition that depends on the dynamics of stresses generated by proliferation and differentiation. This new link between epithelial fluidity, interkinetic movements and cell cycle dynamics has implications for the precision of pattern formation and could be relevant to multiple developing tissues.

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Cell cycle dynamics control fluidity of the developing mouse neuroepithelium

et al. 2023

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As developing tissues grow in size and undergo morphogenetic changes, their material properties may be altered. Such changes result from tension dynamics at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms controlling the physical state of growing tissues are unclear. We found that at early developmental stages, the epithelium in the developing mouse spinal cord maintains both high junctional tension and high fluidity. This is achieved via a mechanism in which interkinetic nuclear movements generate cell area dynamics that drive extensive cell rearrangements. Over time, the cell proliferation rate declines, effectively solidifying the tissue. Thus, unlike well-studied jamming transitions, the solidification uncovered here resembles a glass transition that depends on the dynamical stresses generated by proliferation and differentiation. Our finding that the fluidity of developing epithelia is linked to interkinetic nuclear movements and the dynamics of growth is likely to be relevant to multiple developing tissues.

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Cell Division: Interkinetic Nuclear… Mechanics

Abstract: New work reveals that interkinetic nuclear migration -the movement of nuclei towards the apical surface of dividing epithelial cells -is mechanically regulated, relying on a balance of forces between the mitotic cell and the surrounding tissue.

Cited by 3 publications

References 18 publications

Mechanical constraints to cell-cycle progression in a pseudostratified epithelium

Mechanical constraints to cell-cycle progression in a pseudostratified epithelium

Cell cycle dynamics controls fluidity of the developing mouse neuroepithelium

Cell cycle dynamics control fluidity of the developing mouse neuroepithelium

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