Cell-Division and Cancer

Szent‐Györgyi, Albert

doi:10.1126/science.149.3679.34

Cited by 105 publications

(25 citation statements)

References 13 publications

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“…Methylglyoxal is a highly reactive substance found in the glycolysis pathway of plants, fungi, bacteria and eukaryotes. It is known to act as an inhibitor of cell division in eukaryotic cancer cells [20]. Further investigations of the effects of honey on the cell cycle, and of specific sugars in bacterial adhesion, biofilm structure and bacterial communication may be useful in producing new classes of antibacterials.…”

Section: Discussionmentioning

confidence: 99%

Bacteria, biofilm and honey: A study of the effects of honey on ‘planktonic’ and biofilm-embedded chronic wound bacteria

Merckoll

Jonassen

Vad

et al. 2009

Scandinavian Journal of Infectious Diseases

113

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Chronically infected wounds are a costly source of suffering. An important factor in the failure of a sore to heal is the presence of multiple species of bacteria, living cooperatively in highly organized biofilms. The biofilm protects the bacteria from antibiotic therapy and the patient's immune response. Honey has been used as a wound treatment for millennia. The components responsible for its antibacterial properties are now being elucidated. The study aimed to determine the effects of different concentrations of 'Medihoney' therapeutic honey and Norwegian Forest Honey 1) on the real-time growth of typical chronic wound bacteria; 2) on biofilm formation; and 3) on the same bacteria already embedded in biofilm. Reference strains of MRSE, MRSA, ESBL Klebsiella pneumoniae and Pseudomonas aeruginosa were incubated with dilution series of the honeys in microtitre plates for 20 h. Growth of the bacteria was assessed by measuring optical density every 10 min. Growth curves, biofilm formation and minimum bactericidal concentrations are presented. Both honeys were bactericidal against all the strains of bacteria. Biofilm was penetrated by biocidal substances in honey. Reintroduction of honey as a conventional wound treatment may help improve individual wound care, prevent invasive infections, eliminate colonization, interrupt outbreaks and thereby preserve current antibiotic stocks.

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Section: Discussionmentioning

confidence: 99%

Bacteria, biofilm and honey: A study of the effects of honey on ‘planktonic’ and biofilm-embedded chronic wound bacteria

Merckoll

Jonassen

Vad

et al. 2009

Scandinavian Journal of Infectious Diseases

113

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“…SzentGyorgyi [23] intimated that mitoses may be regulated by two antagonistic substances, 'promine', the promoter, and 'refine', the re tarder. Somewhat earlier, Poydock [ 19] found cell division to be controlled by two factors which she called 'growth-promoting' and 'growth-inhibiting' substances.…”

Section: Discussionmentioning

confidence: 99%

Inhibiting Effect of Dehydroascorbic Acid on Cell Division in Ascites Tumors in Mice

Poydock¹,

Reikert²,

Rice³

et al. 1982

Pathobiology

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The transplantable murine ascites tumors, P388 leukemia and Ehrlich carcinoma, demonstrated complete inhibition of mitotic activity after treatment with dehydroascorbic acid in mice. Citric acid at the same pH value (2.4), however, showed no diminution of mitoses. Microscopic examination of the stained ascites exudate taken from the mice treated with 10 mg dehydroascorbic acid revealed few tumor cells and a pronounced increase in white blood cells, whereas the ascites tumor exposed to citric acid appeared normal.

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“…, its accumulation in dystrophic muscle (lo), and its possible role as a carciriostatic agent (11) have resulted in a revived intcrcst in this cornpound.…”

mentioning

confidence: 99%

Synthesis of Methylglyoxal-l4C

Brum

1966

Journal of Pharmaceutical Sciences

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Cell-Division and Cancer

Cited by 105 publications

References 13 publications

Bacteria, biofilm and honey: A study of the effects of honey on ‘planktonic’ and biofilm-embedded chronic wound bacteria

Bacteria, biofilm and honey: A study of the effects of honey on ‘planktonic’ and biofilm-embedded chronic wound bacteria

Inhibiting Effect of Dehydroascorbic Acid on Cell Division in Ascites Tumors in Mice

Synthesis of Methylglyoxal-l4C

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