Cell-derived Secretome for the Treatment of Renal Disease

Kim, Michael W.; Ko, In Kap; Atala, Anthony; Yoo, James J.

doi:10.3339/jkspn.2019.23.2.67

Child Kidney Dis

2019

DOI: 10.3339/jkspn.2019.23.2.67

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Cell-derived Secretome for the Treatment of Renal Disease

Michael W. Kim¹,

In Kap Ko²,

Anthony Atala³

et al.

Abstract: Cell-derived Secretome for the Treatment of Renal Disease Kidney disease is a major global health issue. Hemodialysis and kidney transplantation have been used in the clinic to treat renal failure. However, the dialysis is not an effective long-term option, as it is unable to replace complete renal functions. Kidney transplantation is the only permanent treatment for end-stage renal disease (ESRD), but a shortage of implantable kidney tissues limits the therapeutic availability. As such, there is a dire need t… Show more

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2022

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“…This approach has shown promise in terms of improving renal function, but some safety issues remain to be resolved before the clinical application. These include immune rejection, pulmonary embolism and teratoma formation due to uncontrolled proliferation of pluripotent stem cells (SC) [7,[11][12][13][14]. Stem cells can also act in a paracrine manner by secreting the growth factors and cytokines that can promote regeneration [2,15,16].…”

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Morphological pattern of kidneys in rats with infravesical urinary obstruction following administration of biologically active compositions containing neurotrophic factors

Globa

Божок

Legach

et al. 2022

Ukr. J. Nephrol. and Dial.

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Abstract. The research aimed to study the morphological characteristics of kidneys after intraperitoneal administration of biologically active compositions (BACs) in rats with infravesical obstruction (IVO). Methods. IVO was reproduced by surgical ligation. BACs were injected intraperitoneally for 10 days. The morphometric parameters of the kidneys were determined by examining their structure (the areas of renal corpuscle, glomerulus, the cavity of the glomerular capsule, outer and inner diameters of the tubules, the tubular index, the outer diameter and area of the vascular lumen). The experimental animals were divided into the following groups: Group 1 was saved as an intact control group, Group 2 received “Cortexin”, Group 3 was given CMCNMG, Group 4 received BCM, and Group 5 was not treated (U). Results. BACs obtained from a culture of native mantle gliocytes (MG) and BCM were involved in the remodeling of the kidneys’ structure being changed during IVO. The renal corpuscle area was found to be increased in groups 2, 4, and 5 by 42.3%, 193.9%, and 72.3%, respectively, compared with the control group. At the same time, the extent of renal corpuscle hypertrophy in group 3 was minimal and approached the control values. The glomerulus area expanded by 35.4%, 181.1%, and 34% in animals of groups 3, 4, and 5, respectively, compared with the control group. However, the difference in the index between group 5 and BAC-treated animals was not significant, except for group 4. The Bowman's capsule area increased by 117.6%, 235.8%, and 186%, in groups 2, 4 and 5, respectively, compared with the control group. Interestingly, the values in groups 1 and 3 were in agreement but differed from group 5. The lowest values of outer and inner diameters of renal tubules were determined in group 3, which were close to those in the control group but significantly different from those of other groups. An increased tubular index (by 1.35 and 1.4 times) was revealed in groups 3 and 4, compared with other groups. The lowest values were found in groups 2 and 5. The maximum values of the average diameter and area of the vessel lumen were determined in groups 3 and 4, and the minimum values were obtained in group 5. It is noteworthy that the indices of these groups were significantly different from those of group 5. Conclusions. The research results suggest that the phenomena of glomerulosclerosis, tubular atrophy, and renal interstitial fibrosis in rats can be alleviated, as well as the morphological structure of rat kidneys can be partially restored against the background of IVO after administration of CMCNMG and, to a lesser extent, BCM due to the multidirectional action of neurotrophic factors.

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confidence: 99%

“…Established tubular indices are also indicative, which have been shown to demonstrate a reduction in the progression of the EMT in kidneys due to IVO [3,6,12]. NFs are responsible for the transmission of signals that can alter the behavior and physiology of target cells [19,28].…”

mentioning

confidence: 99%

Morphological pattern of kidneys in rats with infravesical urinary obstruction following administration of biologically active compositions containing neurotrophic factors

Globa

Божок

Legach

et al. 2022

Ukr. J. Nephrol. and Dial.

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Cell-derived Secretome for the Treatment of Renal Disease

Cited by 1 publication

References 82 publications

Morphological pattern of kidneys in rats with infravesical urinary obstruction following administration of biologically active compositions containing neurotrophic factors

Morphological pattern of kidneys in rats with infravesical urinary obstruction following administration of biologically active compositions containing neurotrophic factors

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