Cell-Derived Microparticles Promote Coagulation after Moderate Exercise

Soßdorf, Maik; Otto, Gordon P.; Claus, Ralf A.; Gabriel, Holger; Lösche, Wolfgang

doi:10.1249/mss.0b013e3182068645

Cited by 65 publications

(97 citation statements)

References 40 publications

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“…One reason for these varying results is possibly the amount of training the subjects had received. Some studies have suggested that submaximal exercise in untrained subjects generally had a negative impact, including the activation of blood coagulation [8].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have previously revealed that submaximal exercise may induce inflammation, increase white blood cell count, and activate platelets and a variety of cells, including granulocytes, and thus is able to cause an increased generation of membrane microparticles (MP) [8,10]. In the presented study, exercise slightly inhibited platelet aggregation in the OC(-) group, but there was no effect on aggregation in the OC(+) group, therefore similar behaviour was expected with MP activity.…”

Section: Discussionmentioning

confidence: 99%

“…by unchanged or even inhibited platelet aggregation [5,6,7]. The reasons for these contrasting results are thought to arise from variation in the fitness of the subjects studied or in the amount of physical exercise [8,3,9].…”

Section: Introductionmentioning

confidence: 99%

“…Intense physical activity, often defined as 'submaximal' physical activity (with a heart rate 85% of a maximum calculated for a particular age), can be associated with an inflammatory response and the generation/activation of platelets and various cells, including granulocytes, which are the main source for the generation of membrane microparticles with prothrombotic activity [8,10]. Moreover,it has been demonstrated that platelets and granulocytes, with physical exercise, cause an increase in the expression of tissue factor (TF) in monocytes responsible for the activation of the coagulation process and the generation of thrombin [11].…”

Section: Introductionmentioning

confidence: 99%

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Early response of selected haemostatic and haematological parameters to physical activity in young women – the potential impact of oral contraceptives

Jastrzębska¹,

Żyżniewska-Banaszak²,

Nawrot³

et al. 2017

J Pre Clin Clin Res.

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Early response of selected haemostatic and haematological parameters to physical activity in young women -the potential impact of oral contraceptives. J Pre Clin-Clin Res. 2017; 11(1): 15-21. doi: 10.26444/jpccr/75148 Abstract Introduction and objective. Exercise (submaximal) in untrained subjects can modify haemostasis toward hypercoagulability, especially among women using oral contraceptives (OC). The aim of this study was to investigate whether this can be explained by platelet haemostasis and changes in the generation of membrane microparticles. Materials and method. Young, healthy women (n=60) were divided into 2 equal groups: a study group OC (+) who had used OC for >3 months, and controls who had never used oral contraceptives OC(-). Exclusion criteria: those with systematic daily physical activity. Participants were subjected to treadmill exercise (Cardiac Diagnostic System; model CH2000) using the Bruce protocol/ AHA guidelines. Platelet aggregation with arachidonic acid (ASPI test) or ADP (ADP test), membrane microparticle (MP) activity, plasma coagulation times (APTT/PT) and blood count were determined before and 45 minutes after exercise. Results. Before exercise, the OC(+) group had slightly higher platelet aggregation (ADP test), significantly lower MP activity, slightly lower PLT and slightly higher PDW rate. Exercise caused slight inhibition of platelet aggregation (ASPI test), and significant decrease in MP activity -only in the OC(-) group. After exercise, in both groups there was a significant decrease in PLT and increase in WBC, more pronounced in OC(+) group. Conclusions. Submaximal exercise was beneficial for haemostasis in women not using hormonal contraception, associated primarily with reduced MP activity. No beneficial effects of physical activity were found for women using hormonal contraceptives, possibly associated with a hypercoagulable state, and higher reactivity of blood platelets under the influence of the use of contraceptives.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Early response of selected haemostatic and haematological parameters to physical activity in young women – the potential impact of oral contraceptives

Jastrzębska¹,

Żyżniewska-Banaszak²,

Nawrot³

et al. 2017

J Pre Clin Clin Res.

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“…There was, however, a good deal of overlap between these entities and extensive recent work had indicated that the nature of vesicles varies with the cell of origin and the condition of the cell of origin. Other factors such as gender, age, circadian rhythms, fasting state, medication exposure, and physical activity also may influence the number and nature of vesicles under different conditions [6][7][8][9][10][11]. Vesicles have been studied most extensively in plasma and serum [12], but have also been isolated from pleural effusions [13], ocular effluent and aqueous humor [14], breast milk [15], ascites [16], amniotic fluid [17], semen [18], saliva [19], cerebrospinal fluid [20], and urine [21].…”

Section: Extracellular Vesicles: Basic Considerationsmentioning

confidence: 99%

Cellular Phenotype and Extracellular Vesicles: Basic and Clinical Considerations

Quesenberry

Goldberg²,

Aliotta³

et al. 2014

Stem Cells and Development

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Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise

Giloteaux,

Glass,

Germain

et al. 2024

J of Extracellular Vesicle

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In healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue and reduces the risk of chronic diseases. Although exercise is suggested as a lifestyle intervention to manage various chronic illnesses, it negatively affects people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), who suffer from exercise intolerance. We hypothesized that altered extracellular vesicle (EV) signalling in ME/CFS patients after an exercise challenge may contribute to their prolonged and exacerbated negative response to exertion (post‐exertional malaise). EVs were isolated by size exclusion chromatography from the plasma of 18 female ME/CFS patients and 17 age‐ and BMI‐matched female sedentary controls at three time points: before, 15 min, and 24 h after a maximal cardiopulmonary exercise test. EVs were characterized using nanoparticle tracking analysis and their protein cargo was quantified using Tandem Mass Tag‐based (TMT) proteomics. The results show that exercise affects the EV proteome in ME/CFS patients differently than in healthy individuals and that changes in EV proteins after exercise are strongly correlated with symptom severity in ME/CFS. Differentially abundant proteins in ME/CFS patients versus controls were involved in many pathways and systems, including coagulation processes, muscle contraction (both smooth and skeletal muscle), cytoskeletal proteins, the immune system and brain signalling.

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Cell-Derived Microparticles Promote Coagulation after Moderate Exercise

Cited by 65 publications

References 40 publications

Early response of selected haemostatic and haematological parameters to physical activity in young women – the potential impact of oral contraceptives

Early response of selected haemostatic and haematological parameters to physical activity in young women – the potential impact of oral contraceptives

Cellular Phenotype and Extracellular Vesicles: Basic and Clinical Considerations

Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise

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