Cell density of adrenomedullin‐immunoreactive cells in the gastric endocrine cells decreases in antral atrophic gastritis

Abstract

AM-IR cells are present in the endocrine cells including gastrin-IR cells in the pyloric glands. These results suggest that AM may contribute to gastrin secretion in the pyloric glands.

Chronic Gastritis

“…An increase in proliferative activity of glandular epithelium in gastric mucosa was also observed in chronic gastritis, independently of its etiology (Bechi et al, 1996;Deschner et al, 1972;Irazusta et al, 1998;Panella et al, 1996). It was usually accompanied by a decrease in G cell count, including adrenomodulincontaining cells (Kitani et al, 1999), particularly frequently when the gastritis was associated with atrophic lesions. According to the studies by other authors (Bielicki et al, 1993;Guerci et al, 1992), a significantly higher percentage of cells in division phase is found in chronic atrophic gastritis as compared to both normal condition and to chronic superficial gastritis, and the proliferative activity of glandular epithelial cells is directly proportional to the increasing degree of atrophy.…”

Adrenomedullin regulates intestinal physiology and pathophysiology

“…The digestive system is not an exception and both, AM and PAMP, are reported to be in the salivary glands, esophagus, stomach, duodenum, jejunum, ileum, cecum, colon, gall bladder, bile duct, and pancreas (Table 1) [ 83,126,127,133,134]. Taking into account the vastness of the subject, in this review, we will focus our attention on the stomach and the gut, while briefly summarizing information about the oral cavity, esophagus, and pancreas.…”

“…Both peptide immunoreactivities can be detected in neuroendocrine cells, being specially abundant in the enterochromaffin-like and chief cells of the gastric fundus [124,125] as well as in the base of the glandular epithelia in the pyloric mucosa [126]. Adrenomedullin is also found in the gastrin-containing cells in the pyloric glands [127], and AM mRNA signals are present in nonendocrine cells in the basal half of the mucosa [123]. Tajima et al [123] reported that neuroendocrine cells positively stained for AM and PAMP were frequently found near blood vessels.…”

Immunohistological Localization and Possible Functions of Adrenomedullin

“…In the gastric mucosa, AM-IR cells are predominantly present in pyloric glands and constitute a subpopulation of gastrin-IR cells (53). AM-IR cells and gastrin-IR cells decrease in number with the severity of glandular atrophy.…”