Cell death with predominant apoptotic features in <i>Saccharomyces cerevisiae</i> mediated by deletion of the histone chaperone <i>ASF1/CIA1</i>

Yamaki, Mariko; Umehara, Takashi; Chimura, Takahiko; Horikoshi, Masami

doi:10.1046/j.1365-2443.2001.00487.x

Cited by 87 publications

(70 citation statements)

References 37 publications

(81 reference statements)

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“…Of note, acetic acid does not induce apoptosis in respiratory deficient (rho 0 ) cells and cell death is at least partially inhibited in cells that are unable to synthesize cytochrome c [21]. Several other studies have linked cytochrome c release, ROS formation, and changes in mitochondrial membrane potential to yeast apoptosis, such as heterologous expression of human Bax [24,25] or human α-synuclein [26], and deletion of the histone chaperone ASF1/CIA1 [27].…”

Section: Drug-induced Cell Deathmentioning

confidence: 99%

The mitochondrial pathway in yeast apoptosis

et al. 2007

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Mitochondria are not only important for the energetic status of the cell, but are also the fatal organelles deciding about cellular life and death. Complex mitochondrial features decisive for cell death execution in mammals are present and functional in yeast: AIF and cytochrome c release to the cytosol, mitochondrial fragmentation as well as mitochondrial hyperpolarisation followed by an oxidative burst, and breakdown of mitochondrial membrane potential. The easy accessibility of mitochondrial manipulations such as repression of respiration by growing yeast on glucose or deletion of mitochondrial DNA (rho 0 ) on the one hand and the unique ability of yeast cells to grow on nonfermentable carbon sources by switching on mitochondrial respiration on the other hand have made yeast an excellent tool to delineate the necessity for mitochondria in cell death execution. Yeast research indicates that the connection between mitochondria and apoptosis is intricate, as abrogation of mitochondrial function can be either deleterious or beneficial for the cell depending on the specific context of the death scenario. Surprisingly, mitochondrion dependent yeast apoptosis currently helps to understand the aetiology (or the complex biology) of lethal cytoskeletal alterations, ageing and neurodegeneration. For example, mutation of mitochondrial superoxide dismutase or CDC48/VCP mutations, both T. Eisenberg · S. Büttner · F. Madeo ( ) Institute of Molecular Biosciences, Universitaetsplatz 2, University of Graz, 8010 Graz, Austria e-mail: frank.madeo@uni-graz.at G. Kroemer Apoptosis, Cancer, and Immunity Unit, Institut Gustave Roussy, Faculté Paris Sud-Université, Institut National de la Santé et de la Recherche Médicale, Paris XI, France implicated in several neurodegenerative disorders, are associated with mitochondrial impairment and apoptosis in yeast.

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Section: Drug-induced Cell Deathmentioning

confidence: 99%

The mitochondrial pathway in yeast apoptosis

et al. 2007

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“…Thirty-two genes among 2,449 genes in S. pombe show Homology to heat shock proteins. There were a few functional studies of the fission yeast chaperone such as calnexin (13), cdc37 (14), and Hsp90/Git10 (15), Rsp1p (16), ASF1/CIA1 (17). In our lab, for screening of molecular chaperones without an α-crystalline domain from S. pombe, heat stable proteins were screened from the fission yeast and examined their anti-aggregation activity using the yeast citrate synthase.…”

Section: Introductionmentioning

confidence: 99%

Aspartyl aminopeptidase of Schizosaccharomyces pombe has a molecular chaperone function

Lee

Kim²,

Yun³

et al. 2009

BMB Reports

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“…The apoptotic response of S. cerevisiae has been observed in aging cells (24) and mutants with mutations in ATPase CDC48 (25) or anti-silencing protein ASF1 (26). In addition, weak acidic (27,28), oxidative stress (29), salt stress (30,31), UV irradiation (32), and mating pheromone treatment (33) can also induce apoptosis in yeast cells.…”

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confidence: 99%