Cell death pathology: Perspective for human diseases

Agostini, Massimiliano; Tucci, Paola; Melino, Gerry

doi:10.1016/j.bbrc.2011.09.081

Cited by 49 publications

(29 citation statements)

References 89 publications

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“…Cell death via apoptosis through the stimulation of specific intracellular pathways is a stimulation response of cells to affected microenvironments (22,23). Lethal cytokines, they are members of the TNF superfamily, stimulate decease receptors on the cell surface with consequent stimulation of caspases, central activators, and effectors of apoptosis (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

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Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

et al. 2016

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Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple, large renal cysts and impaired kidney function. Although the reason for the development of kidney cysts is unknown, ADPKD is associated with cell cycle arrest and abundant apoptosis of renal tubular epithelial cells. Aims: We asked whether serum-soluble TNF-related apoptosis-inducing ligand (sTRAIL) might underlie ADPKD. Study Design: Case-control study. Methods: Serum sTRAIL levels were measured in 44 patients with ADPKD and 18 healthy volunteers. The human soluble TRAIL/Apo2L ELISA kit was used for the in vitro quantitative determination of sTRAIL in serum samples. Results:Mean serum sTRAIL levels were lower in patients with ADPKD as compared to the control group (446.9±103.1 and 875.9±349.6 pg/mL, p<0.001). Serum sTRAIL levels did not differ among stages of renal failure in patients with ADPKD. There was no correlation between serum sTRAIL levels and estimated glomerular filtration rate in patients with ADPKD (p>0.05). Conclusion: Our results show that ADPKD patients have depressed sTRAIL levels, indicating apoptosis unrelated to the stage of chronic renal failure.

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Section: Discussionmentioning

confidence: 99%

“…Lethal cytokines, they are members of the TNF superfamily, stimulate decease receptors on the cell surface with consequent stimulation of caspases, central activators, and effectors of apoptosis (23)(24)(25). The apoptotic process is regulated by a host of checks and balances with a many of positive and negative factors (26).…”

Section: Discussionmentioning

confidence: 99%

Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

et al. 2016

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“…Failure to trigger the cellular suicide program not only predisposes to development of malignancies, but also increases the resistance of gliomas to anticancer drugs and irradiation (33). Apoptosis is a tightly regulated form of programmed cell death involving a series of biochemical events (34)(35)(36), in which Bcl-2 gene has been proved to play a critical role in the key events of mitochondrial apoptosis (37)(38)(39). The Bcl-2 belongs to a superfamily of genes known to be involved in the regulation of the cell death process, and is predominantly localized in mitochondria that regulates mitochondrial membrane integrity and cytochrome c release (40,41).…”

Section: Discussionmentioning

confidence: 99%

Expression and correlation of Bcl-2 with pathological grades in human glioma stem cells

2012

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Abstract. The anti-apoptotic gene, B-cell lymphoma-2 (Bcl-2), has been reported to be overexpressed in gliomas and is related to tumor prognosis, suggesting a potential therapeutic target. Additionally, recent studies have demonstrated the existence of brain glioma stem cells (BGSCs) which are tumorigenic, selfrenewable and dominate the biological behavior of gliomas. Currently BGSCs are committed as a new target of glioma therapies. However, few studies have focused on the expression of Bcl-2 in BGSCs. We performed a series of experiments to culture BGSCs from eight clinical specimens, followed by real-time RT-PCR and immunoassays to compare the expression levels of Bcl-2 in BGSCs and their corresponding primary glioma cells (PGCs). The results showed that Bcl-2 mRNA and protein expression levels are higher in BGSCs compared to their counterparts, and the expression levels are related to glioma malignancies. As an anti

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“…Autophagy is a normal physiological process that functions to turn over abnormal proteins and organelles (Lockshin and Zakeri 2004) and is closely related to apoptosis (Martins et al 2011;Galluzzi et al 2008b;Rufini and Melino 2011;Agostini et al 2011). Autophagy can counteract or sustain apoptosis or vise versa and exhibit a typical hormesis phenotype.…”

Section: Autophagy -A Physiological Hormesis Casementioning

confidence: 99%

Hormesis, Cell Death, and Regenerative Medicine for Neurodegenerative Diseases

Wang¹

2012

Dose-Response

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ᮀ Although the adult human brain has a small number of neural stem cells, they are insufficient to repair the damaged brain to achieve significant functional recovery for neurodegenerative diseases and stroke. Stem cell therapy, by either enhancing endogenous neurogenesis, or transplanting stem cells, has been regarded as a promising solution. However, the harsh environment of the diseased brain posts a severe threat to the survival and correct differentiation of those new stem cells. Hormesis (or preconditioning, stress adaptation) is an adaptation mechanism by which cells or organisms are potentiated to survive an otherwise lethal condition, such as the harsh oxidative stress in the stroke brain. Stem cells treated by low levels of chemical, physical, or pharmacological stimuli have been shown to survive better in the neurodegenerative brain. Thus combining hormesis and stem cell therapy might improve the outcome for treatment of these diseases. In addition, since the cell death patterns and their underlying molecular mechanism may vary in different neurodegenerative diseases, even in different progression stages of the same disease, it is essential to design a suitable and optimum hormetic strategy that is tailored to the individual patient.

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Cell death pathology: Perspective for human diseases

Cited by 49 publications

References 89 publications

Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Expression and correlation of Bcl-2 with pathological grades in human glioma stem cells

Hormesis, Cell Death, and Regenerative Medicine for Neurodegenerative Diseases

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