2003
DOI: 10.1016/s0278-6915(03)00002-4
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Cell death induced by the phenolic antioxidant tert-butylhydroquinone and its metabolite tert-butylquinone in human monocytic leukemia U937 cells

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Cited by 82 publications
(56 citation statements)
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“…The activation of the MPT results in the initiation of apoptotic processes. In U937 monocytes, tBHQ altered mitochondrial membrane potential and resulted in the release of cytochrome c (Okubo et al 2003). This is another process where tBHQ-mediated injury and Trx2 function intersects and may relate to factors involved in Nrf2 activation and signaling.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…The activation of the MPT results in the initiation of apoptotic processes. In U937 monocytes, tBHQ altered mitochondrial membrane potential and resulted in the release of cytochrome c (Okubo et al 2003). This is another process where tBHQ-mediated injury and Trx2 function intersects and may relate to factors involved in Nrf2 activation and signaling.…”
Section: Discussionmentioning
confidence: 97%
“…Conversely, overexpression of C93S Trx2 potentiated tBHQ-mediated induction of the expression of all three genes. Asterisks denote a statistically significant difference (p<0.05) from tBHQ-treated empty vector control cultures and the Trx2 or C93S Trx2 transfected cultures contradictory, where tBHQ induces a decrease in GSH in certain cell types but causes an increase in others (Liu et al 1994;Nakagawa et al 1994;Nakagawa 1996;Hara et al 2003;Okubo et al 2003). While our studies did not show a very profound effect on the GSH system, there have been reports of tBHQ-related GSH conjugates in animal models, demonstrating tBHQ's interaction with GSH (Peters et al 1996).…”
Section: Discussionmentioning
confidence: 99%
“…En la industria alimentaria se han utilizado antioxidantes sintéticos como butil-hidroxitolueno (BHT), butil-hidroxianisol (BHA) y terbutil-hidroquinona (TBHQ) para retardar la oxidación de lípidos (Fasseas et al, 2007). Sin embargo, existe preocupación por la utilización de estos antioxidantes sintéticos por su riesgo de toxicidad (Okubo et al, 2003;Rodrí-guez et al 2012).…”
Section: Introductionunclassified
“…This substance is able to significantly obstruct or inhibit the oxidation of a substance that is easily oxidized even in low concentrations, not more than 0.02% of oil or fat contained in food [2]. TBHQ is formed by BHA through an O-methylated process [3]. TBHQ is a preservative in products of fats and oils; animal fat; margarine and similar products; snacks made from potatoes, cereals, flour and starch; and nut products [3].…”
Section: Introductionmentioning
confidence: 99%
“…TBHQ is a preservative in products of fats and oils; animal fat; margarine and similar products; snacks made from potatoes, cereals, flour and starch; and nut products [3]. Although the use of preservatives such as BHA and TBHQ is permitted by the WHO with BHA acceptable daily intake (ADI) of 0.5 mg/kg body weight [3], and TBHQ at 0.70 mg/kg body weight [4][5][6] until now, BHA and TBHQ acceptable consumption still makes controversy because several studies reported that BHA and TBHQ could damage DNA, leading to initiate and promote tumors in several animal tissues. TBHQ can cause the breakdown of DNA in vitro [7] and form 8-hydroxy-2'-deoxyguanosine on Calf Thymus DNA [8].…”
Section: Introductionmentioning
confidence: 99%