Cell death in disease: from 2010 onwards

Knight, Richard; Melino, G

doi:10.1038/cddis.2011.89

Cited by 20 publications

(12 citation statements)

References 124 publications

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“…Indeed, PCD is fundamental for many processes, including: embryogenesis, tissue homeostasis, and immune and stress response. 1 , 2 , 3 , 4 Therefore it has been assumed that PCD had emerged with multicellularity, being absent in unicellular organisms. 3 , 5 , 6 However, it is now clear that PCD also occurs in unicellular eukaryotes and bacteria and is therefore present in all life kingdoms.…”

Section: Open Questionsmentioning

confidence: 99%

Die for the community: an overview of programmed cell death in bacteria

et al. 2015

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Programmed cell death is a process known to have a crucial role in many aspects of eukaryotes physiology and is clearly essential to their life. As a consequence, the underlying molecular mechanisms have been extensively studied in eukaryotes and we now know that different signalling pathways leading to functionally and morphologically different forms of death exist in these organisms. Similarly, mono-cellular organism can activate signalling pathways leading to death of a number of cells within a colony. The reason why a single-cell organism would activate a program leading to its death is apparently counterintuitive and probably for this reason cell death in prokaryotes has received a lot less attention in the past years. However, as summarized in this review there are many reasons leading to prokaryotic cell death, for the benefit of the colony. Indeed, single-celled organism can greatly benefit from multicellular organization. Within this forms of organization, regulation of death becomes an important issue, contributing to important processes such as: stress response, development, genetic transformation, and biofilm formation.

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Section: Open Questionsmentioning

confidence: 99%

Die for the community: an overview of programmed cell death in bacteria

et al. 2015

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“…1 Moreover, in a felicitous conjunction, this coincides with publishing our 1000th paper. This is a remarkable achievement and bears witness to the trust the scientific community places in our journals.…”

mentioning

confidence: 66%

“…Even though it feels like just a few months ago, CDDIS was actually launched in 2010, meaning we are now almost at the ends its 4th year of publication. 1 Moreover, in a felicitous conjunction, this coincides with publishing our 1000th paper. This is a remarkable achievement and bears witness to the trust the scientific community places in our journals.…”

mentioning

confidence: 66%

1000 successes as CDDIS reaches 1000 published papers!

Melino

2014

Cell Death Dis

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“…This phenomenon of orchestrated cell demise is required by multicellular life forms for the sculpting of organs (such as interdigital regions in mammalian limbs; Jacobson et al , 1997 ), removal of undesirable structures (as in the metamorphosis of tadpoles; Nishikawa and Hayashi, 1995 ; Jiang et al , 1997 ), elimination of unhealthy or noxious cells ( Cohen, 1991 ; Ju et al , 1995 ; Asplund-Samuelsson et al , 2012 ), and control of cell number, which pay off as enhanced overall fitness of the organism. Besides, the significance of PCD in stress and immune responses is also well recognized ( Ameisen, 2002 ; Knight and Melino, 2011 ; Favaloro et al , 2012 ; Green and Levine, 2014 ; Allocati et al , 2015 ). As with animals, cell death is essential for plants as the process is involved in growth, differentiation, and stress responses.…”

Section: Introductionmentioning

confidence: 99%

The tale of caspase homologues and their evolutionary outlook: deciphering programmed cell death in cyanobacteria

Bhattacharjee

Mishra

2020

Journal of Experimental Botany

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Programmed cell death (PCD), a genetically orchestrated mechanism of cellular demise, is paradoxically required to support life. As in lower eukaryotes and bacteria, PCD in cyanobacteria is poorly appreciated, despite recent biochemical and molecular evidence that supports its existence. Cyanobacterial PCD is an altruistic reaction to stressful conditions that significantly enhances genetic diversity and inclusive fitness of the population. Recent bioinformatic analysis has revealed an abundance of death-related proteases, i.e. orthocaspases (OCAs) and their mutated variants, in cyanobacteria, with the larger genomes of morphologically complex strains harbouring most of them. Sequence analysis has depicted crucial accessory domains along with the proteolytic p20-like sub-domain in OCAs, predicting their functional versatility. However, the cascades involved in sensing death signals, their transduction, and the downstream expression and activation of OCAs remain to be elucidated. Here, we provide a comprehensive description of the attempts to identify mechanisms of PCD and the existence and importance of OCAs based on in silico approaches. We also review the evolutionary and ecological significance of PCD in cyanobacteria. In the future, the analysis of cyanobacterial PCD will identify novel proteins that have varied functional roles in signalling cascades and also help in understanding the incipient mechanism of PCD morphotype(s) from where eukaryotic PCD might have originated.

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Cell death in disease: from 2010 onwards

Cited by 20 publications

References 124 publications

Die for the community: an overview of programmed cell death in bacteria

Die for the community: an overview of programmed cell death in bacteria

1000 successes as CDDIS reaches 1000 published papers!

The tale of caspase homologues and their evolutionary outlook: deciphering programmed cell death in cyanobacteria

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