Cell damage and proliferation in human gastric mucosa infected by Helicobacter pylori?A comparison before and after H pylori eradication in non-atrophic gastritis

Hoshi, Tatsuya; Sasano, Hironobu; Kato, Kanefusa; Ohara, Shuichi; Shimosegawa, Tooru; Toyota, Takayoshi; Nishimura, Hiroshi

doi:10.1016/s0046-8177(99)90161-2

Cited by 27 publications

(18 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Epidemiological studies have shown that H pylori infection is an important risk factor in gastric cancer [22,47] . Several H pylori virulence-associated genes have been found in Western populations to be associated with an increased risk of gastric cancer and precancerous lesions [48] .…”

Section: Discussionmentioning

confidence: 99%

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

Karaman

Binici²,

Kabalar³

et al. 2008

WJG

View full text Add to dashboard Cite

AIM:To determine, by counting sister chromatid exchange (SCE) frequencies, whether genetic impairment and DNA damage have an effect on the pathogenesis of gastric cancer (GC). METHODS:Analysis of SCE is a cytogenetic technique used to show DNA damage as a result of an exchange of DNA fragments between sister chromatids. We analyzed SCE frequency in 24 patients with GC, 26 patients with chronic atrophic gastritis (CAG), and 15 normal controls. The presence of H pylori was confirmed by urease test, toluidine-blue stain and hematoxylin-eosin stain.RESULTS: SCE was significantly increased in H pylorinegative GC patients, and in H pylori -negative CAG patients compared with controls (7.41 ± 1.36 and 6.92 ± 1.20, respectively, vs 5.54 ± 0.8, P < 0.001). There was no difference in the SCE frequency between H pylorinegative GC patients and H pylori -negative CAG patients (P > 0.05). On other hand, the SCE frequencies in H pylori -positive GC patients were higher than those in H pylori -positive CAG patients (9.20 ± 0.94 vs 7.93 ± 0.81, P < 0.01). Furthermore, H pylori -positive GC patients had a higher SCE frequency than H pylorinegative GC patients (9.20 ± 0.94 vs 7.41 ± 1.36, P < 0.001). Similarly, a significant difference was detected between H pylori -positive CAG patients and H pylori -negative CAG patients (7.93 ± 0.81 vs 6.92 ± 1.20, P < 0.05). CONCLUSION:We suggest the increased SCE in patients reflects a genomic instability that may be operative in gastric carcinogenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

Karaman

Binici²,

Kabalar³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…As a marker of gastric apoptosis associated with gastric inflammation, terminal deoxyuridine nucleotide nick-end labeling (TUNEL) was used in four studies [115,116,117,118]. Fas or soluble Fas ligand was used in two studies [119, 120].…”

Section: Growth Factors Apoptosismentioning

confidence: 99%

“…Fas or soluble Fas ligand was used in two studies [119, 120]. As markers for cell proliferation associated with gastric inflammation, four studies use Ki-67 staining [115, 116, 118, 121] and two studies use proliferating cell nuclear antigen (PCNA) staining [117, 122]. …”

Section: Growth Factors Apoptosismentioning

confidence: 99%

Biomarkers in Patients with Gastric Inflammation: A Systematic Review

et al. 2005

View full text Add to dashboard Cite

Background: The importance of examining the status of gastric inflammation has been acknowledged; the new classification by the updated Sydney system (USS) allows us to evaluate the quantitative status of gastric inflammation. However, this system is based on the histological classification derived from biopsy specimens. Therefore, more convenient, objective and practical biomarkers are recommended. Aim: We undertook a systematic review to find out potential biomarkers by summarizing the relationship between biomarkers and grades of inflammation. Methods: By a primary search via Medline up to December 2004, we extracted a total of 6,526 papers that described biomarkers for human gastric inflammation. All papers were screened by title and abstract. The authors then retrieved 435 citations for complete review; ultimately 231 were appropriate for inclusion criteria. These papers were subclassified into several categories and summarized by each author. Results: In addition to standard markers such as pepsinogens, we confirmed the close relationship between the levels of several biomarkers including gastrin, interleukin-8, HLA class II molecules, reactive oxygen species, and the histological grades. Conclusions: This review provides valuable information describing the clinical implication of these biomarkers for evaluating the static conditions or dynamic alterations of human gastric inflammation.

show abstract

“…9,10 It is also suggested that increased cell proliferation and apoptosis induced by H. pylori infection is important in gastric carcinogenesis. [11][12][13] In adults, apoptosis of the gastric epithelium decreases significantly after H. pylori eradication. 12,14,15 On the other hand, it is not clear whether the increased proliferation of epithelial cells is suppressed after the eradication of H. pylori.…”

Section: Introductionmentioning

confidence: 99%

Gastric epithelial cell turnover and mucosal protection in Japanese children with Helicobacter pylori infection

et al. 2005

View full text Add to dashboard Cite

show abstract

Cell damage and proliferation in human gastric mucosa infected by Helicobacter pylori?A comparison before and after H pylori eradication in non-atrophic gastritis

Cited by 27 publications

References 13 publications

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

Biomarkers in Patients with Gastric Inflammation: A Systematic Review

Gastric epithelial cell turnover and mucosal protection in Japanese children with Helicobacter pylori infection

Contact Info

Product

Resources

About