Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts
Frederika Rentzeperis,
Benjamin Coleman,
Dorothy Wallace
Abstract:Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell… Show more
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