Cell cycle of lymphocytes in mouse thymus

Fabrikant, Jacob I.; Foster, B R

doi:10.1007/bf00597278

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…3. Changes in the cell cycle duration are predominantly due to changes in the duration of G, (Tobey, Anderson and Petersen, 1967;Fabrikant and Foster, 1969;Kimball et al, 1971;Smith and King, 1972). 4.…”

Section: The Control Of Cell Proliferationmentioning

confidence: 99%

The cell cycle and related concepts in cell proliferation

Smith

1982

The Journal of Pathology

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Section: The Control Of Cell Proliferationmentioning

confidence: 99%

The cell cycle and related concepts in cell proliferation

Smith

1982

The Journal of Pathology

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“…A minor population of medium to large sized, rapidly cycling cells are known to generate the bulk of small, nondividing thymocytes [3,7,[13][14][15]. A dif ferent and more recent subdivision is into a minor, medullary, cortisoneresistant population with many peripheral T-cell surface characteristics [low 0 (Thy 1); high H2; TL -ve] and a major, cortical, cortisone-sensi tive population with thymus-unique surface characteristics [high 0 (Thy 1); low H2; TL +ve] [19].…”

Section: Introductionmentioning

confidence: 99%

The Differentiation of T Lymphocytes

Hopper¹,

Rydén²,

Shortman³

1978

Pathobiology

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Dissociated mouse thymocytes were cultured under optimized conditions in Marbrook vessels in order to follow some aspects of T-cell differentiation. Under particular conditions it was possible to obtain a 50% net increase in the total number of the peripheral T-cell like, minor low Θ thymocyte subpopulation over the first day of culture, although this increase was lost with further incubation. The increase arose from proliferation of preexistent low Θ cells, and not from transformation of the major, high Θ population. Under all conditions the high Θ cells died rapidly in culture. These results are in accordance with the view that the high Θ and low Θ thymocytes represent separate streams of T-cell development. There was a striking increase in responsiveness to phytohemagglutinin and con-canavalin A after culture of thymocytes under these conditions. However, this was ascribed, not to the development of new immunocompetent T cells, but to selective cell death in the cultures eliminating some inhibitory elements. No increase in progenitors of cytotoxic lymphocytes was obtained. The results demonstrate some potential artifacts in assessing the immunocompetence of cultured thymocytes.

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Stimulation by epinephrine of adenyl cyclase activity, cyclic AMP formation, DNA synthesis and cell proliferation in populations of rat thymic lymphocytes

MacManus

Whitfield

Youdale

1971

Journal Cellular Physiology

110

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During the first ten minutes after the beginning of a continuous exposure of rat thymocyte populations (maintained in vitro) to epinephrine, there is an increase in the cellular concentration of cyclic AMP. The hormone also increases the activity of a crude preparation of the thymocyte's cyclic AMPforming enzyme, adenyl cyclase. Between 30 and 45 minutes after the beginning of exposure to epinephrine, an additional part of the cell population begins to synthesize deoxyribonucleic acid (DNA). These changes are finally followed two to four hours later by an increase of the flow of cells into mitosis.Since cyclic AMP itself is known to stimulate both the initiation of DNA synthesis and thymocyte proliferation, and since the mitogenic action of epinephrine is shown to be potentiated by caffeine and inhibited by imidazole, it is concluded that the mitogenic action of this hormone is mediated by the cyclic nucleotide.

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Cell cycle of lymphocytes in mouse thymus

Cited by 9 publications

References 6 publications

The cell cycle and related concepts in cell proliferation

The cell cycle and related concepts in cell proliferation

The Differentiation of T Lymphocytes

Stimulation by epinephrine of adenyl cyclase activity, cyclic AMP formation, DNA synthesis and cell proliferation in populations of rat thymic lymphocytes

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