Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

Kimura, Masashi; Matsuda, Yoichi; Yoshioka, Takashi; Okano, Yukio

doi:10.1074/jbc.274.11.7334

Cited by 235 publications

(192 citation statements)

References 36 publications

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“…The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. It plays also a role in meiosis and more particularly in spermatogenesis [23][24][25].…”

Section: Sperm Dna Fragmentation Studiesmentioning

confidence: 99%

Genetic aspects of monomorphic teratozoospermia: a review

Braekeleer

Nguyen

Morel

et al. 2015

J Assist Reprod Genet

103

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Teratozoospermia is characterized by the presence of spermatozoa with abnormal morphology over 85 % in sperm. When all the spermatozoa display a unique abnormality, teratozoospermia is said to be monomorphic. Two forms of monomorphic teratozoospermia, representing less than 1 % of male infertility, are recognized: macrozoospermia (also called macrocephalic sperm head syndrome) and globozoospermia (also called round-headed sperm syndrome). Macrozoospermia is defined as the presence of a very high percentage of spermatozoa with enlarged head and multiple flagella. Meiotic segregation studies in 30 males revealed that over 90 % of spermatozoa were aneuploid, mainly diploid. Sperm DNA fragmentation studies performed in a few patients showed an increase in DNA fragmentation index compared to fertile men. Four mutations in the AURKC gene, a key player in meiosis and more particularly in spermatogenesis, have been found to be responsible for macrozoospermia. Globozoospermia is characterized by round-headed spermatozoa with an absent acrosome, an aberrant nuclear membrane and midpiece defects. The rate of aneuploidy of various chromosomes in spermatozoa from 26 globozoospermic men was slightly increased compared to fertile men. However, this increase was of the same order as that commonly found in infertile men with altered sperm parameters. The majority of the studies found that globozoospermic males had a sperm DNA fragmentation index higher than in fertile men. Mutations or deletions in three genes, SPATA16, PICK1 and DPY19L2, have been shown to be responsible for globozoospermia. Identification of the genetic causes of macrozoospermia and globozoospermia should help refine diagnosis and treatment of these patients, avoiding long and painful treatments. Elucidating the molecular causes of these defects is of utmost importance as intracytoplasmic sperm injection (ICSI) is very disappointing in these two pathologies.

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Section: Sperm Dna Fragmentation Studiesmentioning

confidence: 99%

Genetic aspects of monomorphic teratozoospermia: a review

Braekeleer

Nguyen

Morel

et al. 2015

J Assist Reprod Genet

103

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“…However, it causes a striking alteration in the structure of the centrosome. Speci¢cally, active Nek2 induces a pronounced splitting of centrosomes, characterized by the sepa- [37] Mitotic function? NIMA-related kinases:…”

Section: Polo Kinases and Spindle Formationmentioning

confidence: 99%

Protein kinases in control of the centrosome cycle

et al. 1999

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The centrosome is the major microtubule nucleating center of the animal cell and forms the two poles of the mitotic spindle upon which chromosomes are segregated. During the cell division cycle, the centrosome undergoes a series of major structural and functional transitions that are essential for both interphase centrosome function and mitotic spindle formation. The localization of an increasing number of protein kinases to the centrosome has revealed the importance of protein phosphorylation in controlling many of these transitions. Here, we focus on two protein kinases, the polo-like kinase 1 and the NIMA-related kinase 2, for which recent data indicate key roles during the centrosome cycle.z 1999 Federation of European Biochemical Societies.

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“…In HeLa cells, the Aurora-C protein level is low in G1/S, accumulates during G2/M, and reduces after mitosis, similar to these of Aurora-A and Aurora-B. Immunofluorescence studies showed that Aurora-C is localized to centrosomes from anaphase to cytokinesis [59]. These results suggest that Aurora-C may play a role in centrosome function during the later stages of mitosis.…”

Section: Aurora-cmentioning

confidence: 60%

Function and regulation of Aurora/Ipl1p kinase family in cell division

Dou

Zhang

et al. 2003

Cell Res

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During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipl1p family in mitosis and provides potential links between aberrant regulation of Aurora/Ipl1p kinases and pathogenesis of human cancer.

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Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

Cited by 235 publications

References 36 publications

Genetic aspects of monomorphic teratozoospermia: a review

Genetic aspects of monomorphic teratozoospermia: a review

Protein kinases in control of the centrosome cycle

Function and regulation of Aurora/Ipl1p kinase family in cell division

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