Cell culture replication of herpes simplex virus and, or human cytomegalovirus is inhibited by 3,7-dialkoxylated, 1-hydroxyacridone derivatives

Lowden, Christopher T.; Bastow, Kenneth F.

doi:10.1016/s0166-3542(03)00106-2

Cited by 30 publications

(13 citation statements)

References 21 publications

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“…As for the antiviral properties of this class of compounds, several studies have shown the inhibitory action of acridone derivatives against DNA viruses such as herpes simplex virus and cytomegalovirus [45,46], Epstein-Barr virus [47] and adenovirus [48], as well as RNA viruses, including human immunodeficiency virus [49,50], bovine viral diarrhea virus [51] and hepatitis C [52,53]. The precise target and the mode of action of antiviral acridones are not clearly determined at present, although its predominant action seems to be centered on the synthesis of nucleic acids.…”

Section: Cellular Proteins Involved In Rna Synthesis or Processingmentioning

confidence: 99%

Host Cell Factors as Antiviral Targets in Arenavirus Infection

Linero

Sepúlveda

Giovannoni

et al. 2012

Viruses

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Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle, the targeting of a host process has turned an attractive antiviral approach in the last years for many unrelated virus types. This strategy has the additional benefit to reduce the serious challenge for therapy of RNA viruses to escape from drug effects through selection of resistant variants triggered by their high mutation rate. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing the potential for antiviral developments of diverse host factors essential for virus infection.

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Section: Cellular Proteins Involved In Rna Synthesis or Processingmentioning

confidence: 99%

Host Cell Factors as Antiviral Targets in Arenavirus Infection

Linero

Sepúlveda

Giovannoni

et al. 2012

Viruses

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“…Published literature on natural and synthetic antiviral compounds reveals that the activity against HSV was often dependent on m.o.i. (Akanitapichat et al, 2000;del Barrio & Parra, 2000;Lowden & Bastow, 2003) and/or origin of host cell (Serkedjieva & Ivancheva, 1999;del Barrio & Parra, 2000). The current results indicated that inhibition of PPRV by BExt was much greater with lower (0.01) m.o.i.…”

Section: Resultsmentioning

confidence: 63%

Potential Effect ofAcacia arabica. onPeste des Petits Ruminants. Virus Replication

Balamurugan

Saravanan

Bhanuprakash

et al. 2008

Pharmaceutical Biology

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“…Published work with natural and synthetic compounds showed that activity against HSV is often dependent on multiplicity of infection (Akanitapichat et al, 2000;del Barrio and Parra, 2000;Lowden and Bastow, 2003) and/or host cell (del Barrio and Parra, 2000;Serkedjieva and Ivancheva, 1999). We observed that HSV inhibition of Fr.372 in condition of low virus load was much greater than in high multiplicity infection.…”

Section: Discussionmentioning

confidence: 65%