Cell culture medium supplemented with taurine decreases basic charge variant levels of a monoclonal antibody

Liu, Mengjuan; Wang, Jiaqi; Tang, Hongping; Fan, Li; Zhao, Liang; Wang, Haibin; Zhou, Yan; Tan, Wen‐Song

doi:10.1007/s10529-018-2606-4

Biotechnol Lett

2018

DOI: 10.1007/s10529-018-2606-4

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Cell culture medium supplemented with taurine decreases basic charge variant levels of a monoclonal antibody

Mengjuan Liu

Jiaqi Wang

Hongping Tang

et al.

Abstract: Taurine exhibits noticeable impact on lower basic charge variants, which are mainly due to the decrease of lysine variant and oxidized protein variants.

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Cited by 6 publications

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Multivariate analysis of metabolic parameters and optimization of antibody production using high cell density hybridoma in hollow fiber bioreactors

Liu

Kumari

et al. 2019

Biotechnol Lett

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Cell culture medium supplemented with taurine decreases basic charge variant levels of a monoclonal antibody

Abstract: Taurine exhibits noticeable impact on lower basic charge variants, which are mainly due to the decrease of lysine variant and oxidized protein variants.

Cited by 6 publications

References 13 publications

Multivariate analysis of metabolic parameters and optimization of antibody production using high cell density hybridoma in hollow fiber bioreactors

Multivariate analysis of metabolic parameters and optimization of antibody production using high cell density hybridoma in hollow fiber bioreactors

Rosmarinic acid, a new raw material, doubled monoclonal antibody titer in cell culture manufacturing

Applications of small molecules in modulating productivity and product quality of recombinant proteins produced using cell cultures

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