Cell Culture–Based Tissue Engineering as an Alternative to Bone Grafts in Implant Dentistry: A Literature Review

Abstract

Several biomaterials and techniques for bone grafting have been described in the literature for atresic bone tissue replacement caused by edentulism, surgical resectioning, and traumas. A new technique involves tissue engineering, a promising option to replace bone tissue and solve problems associated with morbidity of autogenous grafting. This literature review aims to describe tissue-engineering techniques using ex vivo cell culture as an alternative to repair bone maxillary atresias and discuss the concepts and potentials of bone regeneration through cell culture techniques as an option for restorative maxillofacial surgery.

Enhanced depth-independent chondrocyte proliferation and phenotype maintenance in an ultrasound bioreactor and an assessment of ultrasound dampening in the scaffold

“…The field of tissue engineering promises to yield substitutes that could potentially overcome the limited availability of native explants [1–3]. For example, tissue engineered neo-cartilage with appropriate biomechanical properties holds promise both for graft applications and as a model system for controlled studies of chondrogenesis [4, 5].…”

Insulin facilitates osteoblast differentiation

“…To find optimal materials for bone defect repair is still a challenge, although a number of materials have been used in bone repair clinics (El‐Ghannam, ; Janicki and Schmidmaier, ). Among those materials, tissue engineering bone materials have increasingly attracted attention (Boeckel et al, ; Wu et al, ). To generate osteoblasts from stem cells is a reasonable strategy, but the efficiency of osteoblast‐generation needs to be improved.…”

The Role of the P2Y2 Nucleotide Receptor in Salivary Gland Regeneration

“…Recent progress has been made in the development of strategies for regeneration and engineering of a variety of tissues, including skin (119,120), corneal epithelium (121), cartilage (122), bone (123,124), bladder (125), and lacrimal (126) and salivary glands (127). Determining the capacity of dispersed cells or tissue fragments to reassemble into native structures and the underlying mechanisms involved should provide novel insights to improve tissue regeneration approaches.…”

“…In contrast, regenerative medicine has revolutionized disease management by offering radical cures to a number of human diseases. Progress has been made in strategies for the regeneration of a variety of tissues including skin (119,120), corneal epithelium (121), cartilage (122), bone (123,124), bladder (125), and lacrimal (126) and salivary glands (127). In this study, we aimed to extend this progress to promote cell-based reconstitution of salivary glands in vitro.…”