Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer

Henderson, G.; Tomlinson, Bernard E.; Gibson, Peter H.

doi:10.1016/0022-510x(80)90048-9

Cited by 257 publications

(108 citation statements)

References 15 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…The number of cells in the human cerebral cortex decreases with increasing age 24 and the function and anatomical structure of the retina also change during aging. 7,9,25,26 It is well known that visual functions such as visual acuity, contrast sensitivity, vernier acuity, and colour vision decrease with increasing age.…”

Section: Discussionmentioning

confidence: 99%

Aging and mfERG topography

Tam

Chan

Brown

et al. 2004

Eye

View full text Add to dashboard Cite

Aim To study the effect of aging retina on the multifocal electroretinogram (mfERG). Methods A total of 18 young subjects (age 18-24 years) and 36 elderly subjects (aged 60-85 years) with intraocular lenses (IOLs) were recruited for this study. No subjects had significant eye diseases or media opacities. mfERG was measured in standard conditions using the VERIS system (version 4.1). There were three groups of 18 subjects: (1) 18-25 years, (2) 60-70 years, and (3) 75-85 years. mfERG responses were grouped into central, paracentral, and peripheral regions for analysis. The N1 amplitude, P1 amplitude, N1 latency, and P1 latency of the first-order responses were analysed. Results Age had no effect on P1 latency, N1 amplitude, and P1 amplitude; however, N1 latencies from central to peripheral regions were significantly longer for group 3 than for group 1. Conclusions This study suggests that measured age-related decreases in mfERG responses are due to optical factors (decrease in retinal light levels, scatter) before the age of 70 years, but neural factors significantly affect mfERG topography after the age of 70 years.

show abstract

Section: Discussionmentioning

confidence: 99%

Aging and mfERG topography

Tam

Chan

Brown

et al. 2004

Eye

View full text Add to dashboard Cite

show abstract

“…Separate processes occurring in aging may contribute differently to the changes in these two regions. Henderson et al (1980) made cell counts in several cortical regions and demonstrated decreases over the adult age range, especiaily in "large neuron"' populations. In that study, as in this one, a large degree of variability among individuals of all ages was observed.…”

Section: Discussionmentioning

confidence: 99%

Cerebral structure on MRI, Part I: Localization of age-related changes

Jernigan

Archibald

Berhow

et al. 1991

Biological Psychiatry

356

179

View full text Add to dashboard Cite

“…However, some populations were recognized to show no loss of neurons with age, eg cranial nerve nuclei [14]. Cerebral cortex [15,16] and hippocampus [17] were thought to be particularly affected, but also cerebellar Purkinje cells [18]. More recent studies employing stereologically-based sampling [19][20][21][22] to derive estimates of neuronal numbers in three-dimensional space have arrived at more conservative conclusions, that neuron loss with ageing is either undetectable or relatively mild [23,24].…”

Section: Microscopic Brain Changes With Agementioning

confidence: 99%

Ageing and the brain

2007

The Journal of Pathology

175

111

View full text Add to dashboard Cite

In this review, the evidence for changes in the human brain with ageing at both the macroscopic and microscopic levels is summarized. Loss of neurons is now recognized to be more modest than initial studies suggested and only affects some neuron populations. Accompanying loss of neurons is some reduction in the size of remaining neurons. This reflects a reduced size of dendritic and axonal arborizations. Some of the likely causes of these changes, including free radical damage resulting from a high rate of oxidative metabolism in neurons, glycation and dysregulation of intracellular calcium homeostasis, are discussed. The roles of genes and environmental factors in causing and responding to ageing changes are explored.

show abstract

Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer

Cited by 257 publications

References 15 publications

Aging and mfERG topography

Aging and mfERG topography

Cerebral structure on MRI, Part I: Localization of age-related changes

Ageing and the brain

Contact Info

Product

Resources

About