Cell competition promotes metastatic intestinal cancer through a multistage process
Ana Krotenberg García,
Mario Ledesma-Terrón,
Joyce Vriend
et al.
Abstract:Cell competition plays an instrumental role in quality control during tissue development and homeostasis. Nevertheless, cancer cells can exploit this process for their own proliferative advantage. In our study, we generated mixed murine organoids and microtissues to explore the impact of cell competition on liver metastasis. Unlike competition at the primary site, the initial effect on liver progenitor cells does not involve the induction of apoptosis. Instead, metastatic competition manifests as a multistage … Show more
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