Cell blocks histopathology versus FNA cytology in diagnosis of primary malignant lung mass: A comparative study

Abdulhameed, Tenya T.; Omer, Jawhar T.; Ali, Salah A.

doi:10.15218/zjms.2017.009

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Lung cancer was found in 57.7% of subjects using the TTFNA cell block technique. Our study results are almost similar to those of Abdulhameed et al (10) at the Rizgary teaching hospital, who reported that the prevalence of lung cancer by means of the TTFNA cell block technique was as high as 57.9%. There were more TTFNA cell block subjects than subjects undergoing TTFNA smears.…”

Section: Discussionsupporting

confidence: 91%

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Diagnostic efficacy cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer

et al. 2021

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BackgroundLung cancer is still the main cause of cancer deaths. The high lung cancer mortality rate is caused by a diagnosis factor or therapy selection. The cell block cytology technique using fine needle aspiration (FNA) samples can provide immunocytochemical material that plays an important role in the differential diagnosis of lung cancer subtypes and in determining immunotherapy administration. This study aimed to determine the sensitivity and specificity of transthoracic FNA (TTFNA) cell block cytology in comparison with bronchial washing smears and TTFNA smears in diagnosing lung cancer. MethodsThis was a cross-sectional diagnostic study involving 26 subjects. All subjects had undergone bronchial washing and CT scan-guided fine needle aspiration followed by cell block preparation. Both direct FNA smears and cell blocks are useful in the diagnostic work-up of patients. Comparative statistical analysis of TTFNA cell block versus bronchial washing smear and TTFNA smear cytology was carried out using the McNemar test. ResultsLung cancer was found in 15 patients (57.7%) using the TTFNA cell block technique. The sensitivity and specificity of the TTFNA cell block technique were 85.7% and 75%, respectively. There was no difference in the positivity value between TTFNA cell block technique of bronchial wash smear technique, and TTFNA smear on lung cancer diagnosis (p>0.05). ConclusionsTransthoracic fine-needle aspiration in combination with the cell block technique has good sensitivity and specificity. The TTFNA can be used for immunocytochemical examinations in lung cancer diagnosis and therapy. This approach is valuable for providing individualized treatment and prognostic evaluations.

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Section: Discussionsupporting

confidence: 91%

“…There has been no study that tested the difference in the positivity of the TTFNA cell block technique and that of the bronchus smear and TTFNA smear techniques. The previous study by Abdulhameed et al (10) who performed different tests for FNA smear and FNA cell block, found no significant difference in positivity.…”

Section: Discussionmentioning

confidence: 86%

Diagnostic efficacy cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer

et al. 2021

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“…Inclusion criteria were patients aged at least 18 years, chest X-ray and chest computer tomography (CT) scan showed pleural effusion accompanied by a peripheral lesion tumor mass and underwent thoracentesis or water-sealed drainage (WSD) procedures, TTNA, and core biopsy who were willing to participate in this study. Exclusion criteria were lung tumor patients with signs of sepsis, history of chemotherapy and/or radiotherapy, thrombocytopenia less than 50,000, international normalized ratio (INR) <1.5, use of mechanical ventilation, history of contralateral pneumonectomy, symptomatic heart failure, uncontrolled cough, and/or no cooperative, suspected hydatid cyst, arteriovenous malformation, bullae around tumor lesions, and mediastinal tumors [10], [11], [12].…”

Section: Methodsmentioning

confidence: 99%

Comparison of the Effectiveness of the Cell Block Method with Core Tissue Biopsy for Adequate Diagnosis of Lung Malignant

Sutanto

Cahya²,

Aphridasari³

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: An adequate diagnosis of lung malignancy can be detected through examination of pleural fluid and Transthoracic needle aspiration (TTNA) based on the cell block method and tissue core biopsy. The cell block method is an immunocytochemical examination method that is useful for the adequate diagnosis of lung malignancy. AIM: This study was to compare the effectiveness of the cell block method with tissue core biopsy on pleural fluid cytology and TTNA cytology to establish the diagnosis of lung malignancy. METHODS: This study is a diagnostic test with an analytical cross-sectional approach on 15 respondents suspected of lung cancer at Dr. Moewardi Hospital Surakarta in September 2021. Subjects underwent pleural fluid cytology, TTNA cytology based on the cell block method, and tissue core biopsy examination. Data analysis used the Kappa test and bivariate analysis to calculate the p-value. RESULTS: The results of the combined examination of pleural fluid cytology and TTNA cytology based on the cell block method gave a very good level of conformity to the tissue core biopsy with a Kappa value of 0.857 and a p-value of 0.001. The results of the combined examination of pleural fluid cytology and TTNA cytology with cell block method showed the highest percentage for sensitivity (100%), NPV (100%), and accuracy (93%); while the results of the TTNA cytology examination using the cell block method showed the highest percentage of specificity (100%) and PPV (100%) of the tissue core biopsy method. CONCLUSION: The cell block method is very effective and significant in assessing the results of combined pleural fluid cytology and TTNA cytology against the tissue core biopsy method so that it is useful for the adequate diagnosis of lung malignant

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Tumor cell representation by an improvised technique of fine-needle aspiration specimen acquisition and cell block preparation: Our experience in lung cancer cases in a peripheral center of eastern India

Boler

Roy

Bandyopadhyay

et al. 2020

J Cytol

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Cell blocks histopathology versus FNA cytology in diagnosis of primary malignant lung mass: A comparative study

Cited by 3 publications

References 11 publications

Diagnostic efficacy cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer

Diagnostic efficacy cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer

Comparison of the Effectiveness of the Cell Block Method with Core Tissue Biopsy for Adequate Diagnosis of Lung Malignant

Tumor cell representation by an improvised technique of fine-needle aspiration specimen acquisition and cell block preparation: Our experience in lung cancer cases in a peripheral center of eastern India

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