Cell-Biomaterial constructs for wound healing and skin regeneration

Safina, Ingrid; Childress, Luke; Myneni, Srinivas R.; Vang, Kieng B.; Biris, Alexandru S.

doi:10.1080/03602532.2021.2025387

Cited by 4 publications

(1 citation statement)

References 213 publications

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“…Hybrid conjugated composite materials can serve as carriers for drugs and growth factors, and control their release rate and dosage. In sports rehabilitation training, appropriate drugs or growth factors can be injected into hybrid composite conjugated materials and implanted into damaged areas to promote tissue repair, reduce inflammatory reactions and accelerate the healing process ( Zhou et al, 2021 ; Safina et al, 2022 ). During the process of exercise rehabilitation, inflammatory reactions are inevitable.…”

Section: Application Of Composite Conjugated Materials In Sports Reha...mentioning

confidence: 99%

Effect of composite conjugated materials on tissue healing during exercise rehabilitation training

Li,

Zhang

2023

Front. Chem.

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The application of traditional materials to tissue healing in sports rehabilitation training has problems such as poor effect, high rejection reaction, and slow healing speed. It also brings many challenges to the development of sports rehabilitation training. This article aims to explore the impact of composite conjugated materials on tissue healing to promote rapid and efficient tissue healing and improve the effect of sports rehabilitation training. Through research and analysis, this article found that composite conjugated materials have unique biocompatibility and can promote cell growth and differentiation. In skin tissue healing, composite conjugated materials can control the release rate and duration of drugs to promote skin healing. During the fracture healing process, conjugated materials can provide growth factors and extracellular matrix components, stimulate bone cell proliferation and differentiation, and promote fracture healing. In terms of soft tissue injuries, composite conjugated materials serve as supporting structures or matrices, providing a favorable environment for the regeneration of damaged tissue. In the regulation of inflammatory responses, composite conjugated materials reduce inflammatory responses and accelerate the healing process by modulating immune responses. The results of this study show that 1 week after the experiment, the skin healing rates of the control group and the experimental group were 42.55% and 58.17% respectively; 5 weeks after the experiment, the skin healing rates of the control group and the experimental group were 51.28% and 73.24% respectively. After 1, 2, 3, 4, and 5 weeks of experiment, it was found that the average tissue repair rates of the control group were 44.03%, 54.18%, 58.40%, 67.08%, and 72.09% respectively, and the average tissue repair rates of the experimental group were 52.18%, 61.91%, 63.40%, 74.61%, and 85.05% respectively. This study highlights the huge potential of composite conjugated materials in promoting tissue healing and tissue repair, and is of great significance for promoting technological progress in the field of sports rehabilitation and improving rehabilitation effects.

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Section: Application Of Composite Conjugated Materials In Sports Reha...mentioning

confidence: 99%

Effect of composite conjugated materials on tissue healing during exercise rehabilitation training

Li,

Zhang

2023

Front. Chem.

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Breaking the boundaries of wound closure: A novel polyurethane tissue adhesive with enhanced healing properties

Zhou,

Shi,

Xia

et al. 2024

J Biomedical Materials Res

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Over the past few decades, there have been advancements in the development of high‐performance tissue adhesives as alternatives to traditional sutures and staples for rapid and effective wound closure post‐surgery. While tissue adhesives offer advantages such as ease of use, short application time, and minimal tissue damage, they also face challenges related to biocompatibility, biodegradability, and adhesive strength. In this study, L‐lysine diisocyanate (LDI) and trimethylolpropane (TMP) were utilized as the primary raw materials to produce a prepolymer terminated with NCO, resulting in the development of a new biocompatible polyurethane tissue adhesive (TMP‐LDI). Additionally, SiO2 nanoparticles were incorporated into the prepolymer, significantly enhancing the adhesive strength of the TMP‐LDI tissue adhesive through the “nanobridging effect,” achieving a strength of 170.4 kPa. Furthermore, the SiO2/TMP‐LDI tissue adhesive exhibited satisfactory temperature change during curing and degradation performance. In vitro and in vivo studies demonstrated that SiO2/TMP‐LDI exhibited good biocompatibility, efficient hemostasis, antimicrobial properties, and the ability to promote wound healing. This research presents a novel approach for the development of tissue adhesives with superior adhesive performance.

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Enhancing wound healing and minimizing scarring: A comprehensive review of nanofiber technology in wound dressings

Jonidi Shariatzadeh,

Currie,

Logsetty

et al. 2025

Progress in Materials Science

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Cell-Biomaterial constructs for wound healing and skin regeneration

Cited by 4 publications

References 213 publications

Effect of composite conjugated materials on tissue healing during exercise rehabilitation training

Effect of composite conjugated materials on tissue healing during exercise rehabilitation training

Breaking the boundaries of wound closure: A novel polyurethane tissue adhesive with enhanced healing properties

Enhancing wound healing and minimizing scarring: A comprehensive review of nanofiber technology in wound dressings

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