2010
DOI: 10.1128/mmbr.00024-10
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Cell Biology of the Trypanosome Genome

Abstract: SUMMARY Trypanosomes are a group of protozoan eukaryotes, many of which are major parasites of humans and livestock. The genomes of trypanosomes and their modes of gene expression differ in several important aspects from those of other eukaryotic model organisms. Protein-coding genes are organized in large directional gene clusters on a genome-wide scale, and their polycistronic transcription is not generally regulated at initiation. Transcripts from these polycistrons are processed by global… Show more

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Cited by 111 publications
(116 citation statements)
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References 197 publications
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“…In the search for new treatments, understanding the basic biology of the parasite is a cornerstone on the path to discovery of novel biological processes that could potentially serve as drug targets (2). Despite the eukaryotic nature of T. brucei, the organism has been shown to harbor many unique biological processes or, in some cases, to extensively utilize mechanisms that are rarely used in higher eukaryotes (3)(4)(5). The exceptional biology of trypanosomes is likely a consequence of their long separate evolutionary history and numerous adaptations to the parasitic lifestyle (6).…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…In the search for new treatments, understanding the basic biology of the parasite is a cornerstone on the path to discovery of novel biological processes that could potentially serve as drug targets (2). Despite the eukaryotic nature of T. brucei, the organism has been shown to harbor many unique biological processes or, in some cases, to extensively utilize mechanisms that are rarely used in higher eukaryotes (3)(4)(5). The exceptional biology of trypanosomes is likely a consequence of their long separate evolutionary history and numerous adaptations to the parasitic lifestyle (6).…”
mentioning
confidence: 99%
“…Strikingly, these organisms accomplish adaptations to changing environments and differentiation to several distinct life cycle forms all in the absence of transcriptional control of their genome (3). Rather, gene expression is regulated at posttranscriptional and posttranslational levels.…”
mentioning
confidence: 99%
“…The transcription of protein-coding genes in Kinetoplastid protists by RNA polymerase II is polycistronic (Palenchar and Bellofatto 2006;Daniels et al 2010). Individual mRNAs are excised by 5 ′ trans splicing of a "spliced leader" (SL) and 3 ′ polyadenylation (Michaeli 2011).…”
Section: Introductionmentioning
confidence: 99%
“…The kinetoplastid genome is arranged in gene clusters, and transcription produces polycistronic transcripts. Regulation of gene expression appears to be primarily posttranscriptional, via modulation of the splicing machinery that generates the mature mRNAs (67). Moreover, their histone sequences and the PTMs that decorate them deviate from what is observed in other eukaryotes (68)(69)(70)(71)(72).…”
Section: Lysine Acetylation In Protozoan Parasitesmentioning
confidence: 99%