Cell biology of posterior capsular opacification

Marcantonio, Julia M.; Vrensen, Gijs F.J.M.

doi:10.1038/eye.1999.126

Cited by 141 publications

(87 citation statements)

References 20 publications

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“…Surgical removal of cataract requires removal of the fiber cells while the lens capsule and epithelium remains in the eye, and the capsular bag is filled with an artificial lens. In nearly 50% of cataract surgeries, the uncontrolled proliferation, migration and aberrant differentiation of equatorial lens epithelial cells remaining after cataract surgery are the cause of posterior capsular opacification (PCO) or secondary cataract (Marcantonio and Vrensen, 1999). Specific therapies to target PCO are an intensive area of basic and clinical research.…”

Section: Posterior Capsular Opacificationmentioning

confidence: 99%

The lens epithelium: Focus on the expression and function of the α-crystallin chaperones

Andley

2008

The International Journal of Biochemistry & Cell Biology

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Lens epithelial cells are the parental cells responsible for growth and development of the transparent ocular lens. Many elegant investigations into their biology have focused on the factors that initiate and regulate lens epithelial cell differentiation. Because they serve key transport and cell maintenance functions throughout life, and are the primary source of metabolic activity in the lens, mechanisms to maintain lens epithelial cell integrity and survival are critical for lens transparency. The molecular chaperones α-crystallins are abundant proteins synthesized in the differentiated lens fiber cell cytoplasm. However, their expression in lens epithelial cells has only been appreciated very recently. Besides their important roles in the refractive and light focusing properties of the lens, α-crystallins have been implicated in a number of non-refractive pathways including those involving stress response, apoptosis and cell survival. The most convincing evidence for their importance in the lens epithelium has been shown by studies on the properties of lens epithelial cells from αA and αB-crystallin gene knockout mice. The effective combination of genetics, cell and molecular biology possible with lens epithelial cells is attracting an increasing number of researchers focused on understanding how lens epithelial cells coordinate survival, proliferation and differentiation. Cell facts• Lens epithelial cells are responsible for the growth and development of the entire ocular lens • Lens development is controlled by cell cycle regulators, signaling molecules and growth factors such as FGF • Lens epithelial cells express members of the small heat shock protein family of molecular chaperones, αA and βB-crystallins, the first crystallins to be expressed during lens development • α-Crystallins likely protect lens epithelial cells from environmental stress throughout life, and thus may delay the onset of age-related cataract • Lens epithelial cell proliferation is deregulated in posterior capsule opacification leading to secondary cataract, a complication in up to 50% of cataract surgeries Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers

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Section: Posterior Capsular Opacificationmentioning

confidence: 99%

The lens epithelium: Focus on the expression and function of the α-crystallin chaperones

Andley

2008

The International Journal of Biochemistry & Cell Biology

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“…[2][3][4] Capsular opacification takes place due to proliferation, migration, and differentiation of residual lens epithelial cells (LECs). 5 These LECs attempt to undergo normal differentiation or epithelial mesenchymal transition (EMT), and consequently form heterogeneous groups of cells in the anterior capsule opacification (ACO) and posterior capsule opacification (PCO). These myofibroblasts type of cells lead to fibrosis of the remnant capsule.…”

Section: Introductionmentioning

confidence: 99%

Impact of anterior capsule polishing on anterior capsule opacification after cataract surgery: a randomized clinical trial

Shah

Praveen

Kaul

et al. 2008

Eye

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“…A cirurgia de catarata, portanto, torna-se muitas vezes necessária em pacientes portadores de glaucoma (2) e a principal complicação desta cirurgia é a opacificação da cápsula posterior (3)(4)(5)(6)(7)(8) . Um defeito na camada de fibras nervosas (CFN) da retina representa um achado precoce do glaucoma, precedendo as alterações biomicroscópicas no nervo óptico (9) e campo visual (10) .…”

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Análise da camada de fibras nervosas pelo GDx em pacientes pseudofácicos com opacidades da cápsula posterior

Arraes¹,

Cavalcanti²,

Arraes³

et al. 2008

Arq. Bras. Oftalmol.

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Cell biology of posterior capsular opacification

Cited by 141 publications

References 20 publications

The lens epithelium: Focus on the expression and function of the α-crystallin chaperones

The lens epithelium: Focus on the expression and function of the α-crystallin chaperones

Impact of anterior capsule polishing on anterior capsule opacification after cataract surgery: a randomized clinical trial

Análise da camada de fibras nervosas pelo GDx em pacientes pseudofácicos com opacidades da cápsula posterior

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