Cell Biology

Sinden, Robert E.

doi:10.1016/b978-0-12-407150-6.50010-9

Cited by 31 publications

(20 citation statements)

References 157 publications

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“…In stark contrast, gametocytes of P. falciparum, which in the immature forms have a similar pellicle organization (plasma membrane, inner pellicle vacuoles, and microtubules), but which are not motile, apparently lack these microtubule-associated linear ar- rays (Meszoely et al, 1987). Recognizing that others have illustrated electron-dense connections between the microtubules and the inner membrane (Sinden, 1978;Dubremetz et al, 1979), one is led to the conclusion that the microtubules and linear-arrayed IMPs are physically and functionally connected (Figs. 7a and 7c).…”

Section: Discussionmentioning

confidence: 84%

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Cryofracture Electron Microscopy of the Ookinete Pellicle of Plasmodium gallinaceum Reveals the Existence of Novel Pores in the Alveolar Membranes

Raibaud

Lupetti

Rácz

et al. 2001

Journal of Structural Biology

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Section: Discussionmentioning

confidence: 84%

“…The development of Plasmodium is characterized by its three life phases: asexual multiplication, sexual development, and invasion (Sinden, 1978). There are three motile invasive stages: the ookinete, the sporozoite, and the merozoite.…”

Section: Introductionmentioning

confidence: 99%

Cryofracture Electron Microscopy of the Ookinete Pellicle of Plasmodium gallinaceum Reveals the Existence of Novel Pores in the Alveolar Membranes

Raibaud

Lupetti

Rácz

et al. 2001

Journal of Structural Biology

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“…Immediately after transmission by mosquito bite, mammalian Plasmodium sporozoites begin to migrate in the skin, gradually enter dermal capillaries (Sidjanski and Vanderberg, 1997;Vanderberg and Frevert, 2004;Amino et al, 2006), travel to the liver and undergo a first round of multiplication in hepatocytes (Sinden, 1978;Hollingdale, 1985). According to our current (Frevert, 2004;Frevert et al, 2006a, b), the initial sporozoite arrest in the liver sinusoid is mediated by unique stellate cell-derived extracellular matrix proteoglycans (Gressner and Schäfer, 1989;Cerami et al, 1992;Frevert et al, 1993;Lyon et al, 1994;Robson et al, 1995;Pinzon-Ortiz et al, 2001;Pradel et al, 2002Pradel et al, , 2004.…”

Section: Introductionmentioning

confidence: 99%

Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken

Frevert¹,

Späth²,

Yee³

2008

International Journal for Parasitology

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Plasmodium gallinaceum typically causes sub-clinical disease with low mortality in its primary host, the Indian jungle fowl Gallus sonnerati. Domestic chickens of European origin, however, are highly susceptible to this avian malaria parasite. Here we describe the development of P. gallinaceum in young White Leghorn chicks with emphasis on the primary exoerythrocytic phase of the infection. Using various regimens for infection, we found that P. gallinaceum induced a transient primary exoerythrocytic infection followed by a fulminant lethal erythrocytic phase. Prerequisite for the appearance of secondary exoerythrocytic stages was the development of a certain level of parasitemia. Once established, secondary exoerythrocytic stages could be propagated from bird to bird for several generations without causing fatalities. Infected brains contained large secondary exoerythrocytic stages in capillary endothelia, while in the liver primary and secondary erythrocytic stages developed primarily in Kupffer cells and remained smaller. At later stages, livers exhibited focal hepatocyte necrosis, Kupffer cell hyperplasia, stellate cell proliferation, inflammatory cell infiltration and granuloma formation. Because P. gallinaceum selectively infected Kupffer cells in the liver and caused a histopathology strikingly similar to mammalian species, this avian Plasmodium species represents an evolutionarily closely related model for studies on the hepatic phase of mammalian malaria.

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“…A recent systems biology-based comparison of the P. berghei proteome at different points in the life cycle revealed that ookinetes, which traverse across the mid gut epithelium of the mosquito, exhibit increased expression of proteins required for a mitochondrial respiratory chain. This expression profile is supported by ultra-structural changes to mitochondrial morphology that occur during the malarial parasite life cycle-ookinetes, but not asexual blood stages, have well-developed cristate mitochondria (Sinden 1978). Moreover, it suggests a metabolic switch to oxidative phosphorylation during development in the mosquito (Hall et al 2005), because either alternative carbon sources are available or the parasite needs to have a more efficient metabolism at this point in its life cycle.…”

Section: Comparative Metabolism: Survival Within a Nichementioning

confidence: 68%

Niche metabolism in parasitic protozoa

Ginger

2005

Phil. Trans. R. Soc. B

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Complete or partial genome sequences have recently become available for several medically and evolutionarily important parasitic protozoa. Through the application of bioinformatics complete metabolic repertoires for these parasites can be predicted. For experimentally intractable parasites insight provided by metabolic maps generated in silico has been startling. At its more extreme end, such bioinformatics reckoning facilitated the discovery in some parasites of mitochondria remodelled beyond previous recognition, and the identification of a non-photosynthetic chloroplast relic in malarial parasites. However, for experimentally tractable parasites, mapping of the general metabolic terrain is only a first step in understanding how the parasite modulates its streamlined, yet still often puzzlingly complex, metabolism in order to complete life cycles within host, vector, or environment. This review provides a comparative overview and discussion of metabolic strategies used by several different parasitic protozoa in order to subvert and survive host defences, and illustrates how genomic data contribute to the elucidation of parasite metabolism.

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Cell Biology

Cited by 31 publications

References 157 publications

Cryofracture Electron Microscopy of the Ookinete Pellicle of Plasmodium gallinaceum Reveals the Existence of Novel Pores in the Alveolar Membranes

Cryofracture Electron Microscopy of the Ookinete Pellicle of Plasmodium gallinaceum Reveals the Existence of Novel Pores in the Alveolar Membranes

Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken

Niche metabolism in parasitic protozoa

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