Cell biological regulation of division fate in vertebrate neuroepithelial cells

Willardsen, Minde I.; Link, Brian A.

doi:10.1002/dvdy.22684

Cited by 33 publications

(31 citation statements)

References 171 publications

(213 reference statements)

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“…During vertebrate retinal patterning, apical-basal gradients of various signaling environments can control cell-type specification (Del Bene et al, 2008; reviewed by Willardsen and Link, 2011). Similar mechanisms may play a role in zebrafish retinal regeneration.…”

Section: Differentiation Of New Neurons and Gliamentioning

confidence: 99%

Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina

Gorsuch

Hyde

2014

Experimental Eye Research

113

131

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This article examines our current knowledge underlying the mechanisms involved in neuronal regeneration in the adult zebrafish retina. Zebrafish, which has the capacity to regenerate a wide variety of tissues and organs (including the fins, kidney, heart, brain, and spinal cord), has become the premier model system to study retinal regeneration due to the robustness and speed of the response and the variety of genetic tools that can be applied to study this question. It is now well documented that retinal damage induces the resident Müller glia to dedifferentiate and reenter the cell cycle to produce neuronal progenitor cells that continue to proliferate, migrate to the damaged retinal layer and differentiate into the missing neuronal cell types. Increasing our understanding of how these cellular events are regulated and occur in response to neuronal damage may provide critical information that can be applied to stimulating a regeneration response in the mammalian retina. In this review, we will focus on the genes/proteins that regulate zebrafish retinal regeneration and will attempt to critically evaluate how these factors may interact to correctly orchestrate the definitive cellular events that occur during regeneration.

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Section: Differentiation Of New Neurons and Gliamentioning

confidence: 99%

Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina

Gorsuch

Hyde

2014

Experimental Eye Research

113

131

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“…The centrosome in G1 cells is comprised of two centrioles, termed the mother and daughter centriole. Each of the two centrioles in the centrosome self-duplicates once during the cell cycle, but their rate of maturation is asymmetric [37]. Upon self-duplication, both centrioles become mother centrioles with newly associated daughter centrioles.…”

Section: Ciliary Proteins - Beyond the Ciliummentioning

confidence: 99%

Cilia, Wnt signaling, and the cytoskeleton

May-Simera

Kelley

2012

Cilia

133

117

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Primary cilia have recently been highlighted as key regulators in development and disease. This review focuses on current work demonstrating the broad role of cilia-related proteins in developmental signaling systems. Of particular consideration is the importance of the basal body region, located at the base of the cilium, in its role as a focal point for many signaling pathways and as a microtubule organizing center. As the cilium is effectively a microtubular extension of the cytoskeleton, investigating connections between the cilium and the cytoskeleton provides greater insight into signaling and cell function. Of the many signaling pathways associated with primary cilia, the most extensively studied in association with the cytoskeleton and cytoskeletal rearrangements are both canonical and non-canonical Wnt pathways. One of the key concepts currently emerging is a possible additional role for the traditionally 'cilia-related' proteins in other aspects of cellular processes. In many cases, disruption of such processes manifests at the level of the cilium. While the involvement of cilia and cilia-related proteins in signaling pathways is currently being unraveled, there is a growing body of evidence to support the notion that ciliary proteins are required not only for regulation of Wnt signaling, but also as downstream effectors of Wnt signaling. This review summarizes recent advances in our understanding of the involvement of cilia and basal body proteins in Wnt signaling pathways.

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“…During the development of the mammalian central nervous system, neural stem/progenitor cells generate neurons through a combination of asymmetric and symmetric divisions (Farkas and Huttner, 2008; Gotz and Huttner, 2005; Huttner and Kosodo, 2005; Willardsen and Link, 2011). All neurons of the mammalian central nervous system derive from a neuroepithelium.…”

Section: Characteristics Of Mammalian Stem Cellsmentioning

confidence: 99%

New Insights into Mechanisms of Stem Cell Daughter Fate Determination in Regenerative Tissues

Sada

Tumbar

2013

International Review of Cell and Molecular Biology

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Stem cells can self-renew and differentiate over extended periods of time. Understanding how stem cells acquire their fates is a central question in stem cell biology. Early work in Drosophila germ line and neuroblast showed that fate choice is achieved by strict asymmetric divisions that can generate each time one stem and one differentiated cell. More recent work suggests that during homeostasis, some stem cells can divide symmetrically to generate two differentiated cells or two identical stem cells to compensate for stem cell loss that occurred by direct differentiation or apoptosis. The interplay of all these factors ensures constant tissue regeneration and the maintenance of stem cell pool size. This interplay can be modeled as a population-deterministic dynamics that, at least in some systems, may be described as stochastic behavior. Here, we overview recent progress made on the characterization of stem cell dynamics in regenerative tissues.

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Cell biological regulation of division fate in vertebrate neuroepithelial cells

Cited by 33 publications

References 171 publications

Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina

Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina

Cilia, Wnt signaling, and the cytoskeleton

New Insights into Mechanisms of Stem Cell Daughter Fate Determination in Regenerative Tissues

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