“…Importantly, the transcription factor cascade that drives neuronal differentiation regulates the expression of Cadherins (Itoh et al, 2013;Rousso et al, 2012), reduction of which impacts adherens junctions and the linked intra-cellular actin network in the apical endfoot. These steps prefigure the delamination of newborn neurons from the ventricular surface in a process that involves local actin and microtubule cytoskeletal re-configuration (Camargo Ortega et al, 2019;Kasioulis and Storey, 2018;Kawaguchi, 2020) and in the chick and mouse neural tube, abscission of the apical membrane and dismantling of primary cilium (Das and Storey, 2014;Kasioulis et al, 2017), reviewed in (Kasioulis and Storey, 2018;Paridaen and Huttner, 2014). The presence of apical microvilli has been documented using electron microscopy (Shepard et al, 1997(Shepard et al, , 1993Smith et al, 1982;Waterman, 1976) and immunofluorescence (Marzesco et al, 2005;Weigmann et al, 1997).…”