Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease

Fadilah, S A W; Law, Zhe Kang; Ismail, Nor Azimah; Lai, Nai Ming

doi:10.1002/14651858.cd011742.pub3

Cited by 17 publications

(11 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the numerous preclinical and clinical studies demonstrating safety and therapeutic benefits in ALS patients and animal models, large, prospective RCTs with long-term follow-up are still needed to identify the safety, efficacy and optimal dose of these therapies [ 124 , 125 ].…”

Section: Prospective Disease-modifying Therapiesmentioning

confidence: 99%

A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?

Shen

Gao

et al. 2021

Transl Neurodegener

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons, leading to paralysis and eventually death. Symptomatic treatments such as inhibition of salivation, alleviation of muscle cramps, and relief of spasticity and pain still play an important role in enhancing the quality of life. To date, riluzole and edaravone are the only two drugs approved by the Food and Drug Administration for the treatment of ALS in a few countries. While there is adequate consensus on the modest efficacy of riluzole, there are still open questions concerning the efficacy of edaravone in slowing the disease progression. Therefore, identification of novel therapeutic strategies is urgently needed. Impaired autophagic process plays a critical role in ALS pathogenesis. In this review, we focus on therapies modulating autophagy in the context of ALS. Furthermore, stem cell therapies, gene therapies, and newly-developed biomaterials have great potentials in alleviating neurodegeneration, which might halt the disease progression. In this review, we will summarize the current and prospective therapies for ALS.

show abstract

Section: Prospective Disease-modifying Therapiesmentioning

confidence: 99%

A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?

Shen

Gao

et al. 2021

Transl Neurodegener

View full text Add to dashboard Cite

show abstract

“…We took issue and oppose Bilal Philips with his open attachments to the likes of Ali Tamimi, Zarabozo, JIMAS 45 , and others known for their hizbiyyah and deviation, and going to the platforms of the likes of these people-all of whom are known to be amongst the Harakiyyoon, upon the manhaj of Safar and Salman and Abdur-Rahmaan Abdul-Khaaliq and others. (Abdul-Wahid 2002) Elsewhere, Abu Khadeejah, in his short article published on his website revealingly titled "Bilal Philips the Deceitful Defender of Ahl ul Bida," has singled out Philips specifically as a proponent of innovation bida'a (usually understood to be an antonym of sunna) and a proponent of "Ikhwaanee Manhaj" 46 that has led many Salafi youth away from the authentic Salafi manhaj. 47 He lists a number of quotes by Philips dating back to the early 2000s, accusing Philips of: (i) Being a proponent of a 42 Or, more precisely, those who maintain political status quo, especially in the context of Saudi Arabia and the Gulf States.…”

Section: Critique Of Bilal Philips' Ideas By Salafis In the Westmentioning

confidence: 99%

Bilal Philips as a Proponent of Neo-Traditional Salafism and His Significance for Understanding Salafism in the West

Duderija

Rasool

2019

Religions

View full text Add to dashboard Cite

This article aims to explain the ideas and the significance of Dr. Bilal Philips, a prominent 'Salafi'preacher, a major proponent of Neo-Traditional Salafism, and how his writings and activities can aid us in understanding the dynamics regarding the nature of Salafism in the West as a discursive tradition with deep roots in the Islamic intellectual history, as well as an element of global Salafi movements. As such, the article focuses primarily on identifying and analyzing Philips' ideas on what constitutes a proper approach to interpreting the Qur'ān and Sunna in the light of the Islamic legal and exegetical tradition. After discussing the reasons why the ideas of Philips are significant for understanding Salafism in the West, the article focuses on his views on the conceptual relationship between sunna and hadīth, the broader hermeneutic characterization of the main four Sunni schools of thought (madhāhib), and issues pertaining to the correct methodology of Qur'ānic exegesis (tafsīr). The article also discusses the internal factionalism and the contentedness of the category of Salafism among western Salafis by examining one critique levelled at Philips by his fellow Salafis residing in the West, with the view of not only understanding and situating the views of Philips more accurately but also to provide an avenue to understand the internal Salafi dynamics in the West in particular. 1 https://islamiconlineuniversity.com/islamic-studies-faculties/. 2 http://tsd-l.worldcat.org/title/exorcism-in-islam/oclc/669684809&referer=brief_results. 3 http://www.newmuslim.net/quran-sunnah/hadith-the-second-fundamental-source-of-guidance/.

show abstract

“…The results of these studies should lead to the creation of new and effective methods to treat a variety of diseases. The conclusions of some authors performing meta-analyses and systematic reviews of MSCs' effectiveness at the preclinical stage seem to be encouraging [16][17][18]; conversely, the results from several clinical systematic reviews and meta-analyses are not [19][20][21][22]. Thus, the efficacy observed during research has not yet provided the basis for a practical medicinal breakthrough.…”

Section: Introductionmentioning

confidence: 99%

Local and Remote Effects of Mesenchymal Stem Cell Administration on Skin Wound Regeneration

et al. 2021

View full text Add to dashboard Cite

Wound healing is an important medical problem. We evaluated the efficacy of locally administered mesenchymal stem cells (MSCs) isolated from human umbilical cords on the dynamics of skin wound healing. The study was conducted on the backs of Wistar rats, where two square wounds were created by removing all layers of the skin. Four groups were studied in two series of experiments: (1) a Control_NaCl group (the wounds were injected with 0.9% NaCl solution) and a Control_0 group (intact wounds on the opposite side of the same rat’s back); (2) an MSC group (injected MSCs, local effect) and a Control_sc group (intact wounds on the opposite side of the back, remote MSC effect). The area and temperature of the wounds and the microcirculation of the wound edges were measured. Histological and morphometric studies were performed on days 3 and 7 after the wounds were created. The results showed that the injection trauma (Control_NaCl) slowed the regeneration process. In both MSC groups (unlike in either control group), we observed no increase in the area of the wounds; in addition, we observed inhibition of the inflammatory process and improved wound regeneration on days 1–3 in the remote group and days 1–5 in the local (injected) group. The MSC and Control_sc groups demonstrated improved microcirculation and suppression of leukocyte infiltration on day 3. On day 7, all the studied parameters of the wounds of the Control_0 group were the same as those of the wounds that received cell therapy, although in contrast to the results of the Control_ NaCl group, fibroblast proliferation was greater in the MSC and Control_sc groups. The dynamics of the size of the wounds were comparable for both local and remote application of MSCs. Thus, even a one-time application of MSCs was effective during the first 3–5 days after injury due to anti-inflammatory processes, which improved the regeneration process. Remote application of MSC, as opposed to direct injection, is advisable, especially in the case of multiple wounds, since the results were indistinguishable between the groups and injection trauma was shown to slow healing.

show abstract

Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease

Cited by 17 publications

References 88 publications

A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?

A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?

Bilal Philips as a Proponent of Neo-Traditional Salafism and His Significance for Understanding Salafism in the West

Local and Remote Effects of Mesenchymal Stem Cell Administration on Skin Wound Regeneration

Contact Info

Product

Resources

About