Cell-based carrier for targeted hitchhiking delivery

Liu, Tonggong; Cheng, Gao; Gu, Dayong; Tang, Huanwen

doi:10.1007/s13346-022-01149-y

Cited by 10 publications

(6 citation statements)

References 96 publications

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“…Therefore, it was suggested that most of the RBCs were involved in the hitchhiking process of the MTX-LDH drug-delivery system [60,61]. A similar pattern of particle attachment on RBCs was previously reported as RBC hitchhiking [60,62,63]. Generally, this kind of non-covalent attachment of a nanocarrier in this manner is chosen as a strategy to boost the delivery effect of nanocarriers to target organs by dramatically enhancing the systemic circulation [64].…”

Section: Nanoparticle Attachment On the Surface Of Rbcsmentioning

confidence: 57%

Blood Compatibility of Drug–Inorganic Hybrid in Human Blood: Red Blood Cell Hitchhiking and Soft Protein Corona

Xie,

Kim,

Kamada

et al. 2023

Materials

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A drug-delivery system consisting of an inorganic host—layered double hydroxide (LDH)—and an anticancer drug—methotrexate (MTX)—was prepared via the intercalation route (MTX-LDH), and its hematocompatibility was investigated. Hemolysis, a red blood cell counting assay, and optical microscopy revealed that the MTX-LDH had no harmful toxic effect on blood cells. Both scanning electron microscopy and atomic force microscopy exhibited that the MTX-LDH particles softly landed on the concave part inred blood cells without serious morphological changes of the cells. The time-dependent change in the surface charge and hydrodynamic radius of MTX-LDH in the plasma condition demonstrated that the proteins can be gently adsorbed on the MTX-LDH particles, possibly through protein corona, giving rise to good colloidal stability. The fluorescence quenching assay was carried out to monitor the interaction between MTX-LDH and plasma protein, and the result showed that the MTX-LDH had less dynamic interaction with protein compared with MTX alone, due to the capsule moiety of the LDH host. It was verified by a quartz crystal microbalance assay that the surface interaction between MTX-LDH and protein was reversible and reproducible, and the type of protein corona was a soft one, having flexibility toward the biological environment.

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Section: Nanoparticle Attachment On the Surface Of Rbcsmentioning

confidence: 57%

Blood Compatibility of Drug–Inorganic Hybrid in Human Blood: Red Blood Cell Hitchhiking and Soft Protein Corona

Xie,

Kim,

Kamada

et al. 2023

Materials

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“…49 Based on these, cells are promising in designing and fabricating various types of bionic delivery robots due to their natural advantages. 50 Synthetic micro/ nanorobots are envisioned to move, sense, and perform specific functions like their biological counterparts. 51 Below, we present several examples of micro-robots using cells as substrate materials for synthesizing microrobots.…”

Section: Cell-based Micro/nanorobotsmentioning

confidence: 99%

Intelligent micro/nanorobots based on biotemplates

Chen,

Cai,

Ren

et al. 2024

Mater. Horiz.

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“…10 This "off-target" property damages normal tissue and organs, produces numerous side effects, reduces the quality of life of patients, and affects the effectiveness of chemotherapy to a certain extent. 11,12 The unsolved limitations have triggered researchers to escalate and alter the original nanoplatforms.…”

Section: Introductionmentioning

confidence: 99%

Advances in Tumor Targeting Biomimetic Drug Delivery Systems: A Promising Approach for Antitumor Therapy

Mo,

He,

et al. 2024

Pharmaceutical Fronts

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Cancer is one of the most fatal diseases that attract numerous efforts and attention from researchers. Among plentiful therapeutic agents, chemotherapy is frequently used in treating virulent tumors, and its insistent administration is useful in the ablation of cancers; however, it also produces side effects. Biomimetic drug delivery systems (BDDSs) provide an alternative route for antitumor therapy. Their endogenous substances may be extracellular vesicles, living cells, cell membranes, etc., which optimize single-agent chemotherapy. They “upgrade” traditional drug delivery platforms by combining the original drug with itself, disguised as a Trojan Horse, to trick the immune system or tumor tissues to achieve higher targeting and lower immunogenicity. Herein, we review three BDDS strategies being used recently in antitumor drug development and their advances, aiming at providing general guidelines and opportunities in this field in the future.

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Cell-based carrier for targeted hitchhiking delivery

Cited by 10 publications

References 96 publications

Blood Compatibility of Drug–Inorganic Hybrid in Human Blood: Red Blood Cell Hitchhiking and Soft Protein Corona

Blood Compatibility of Drug–Inorganic Hybrid in Human Blood: Red Blood Cell Hitchhiking and Soft Protein Corona

Intelligent micro/nanorobots based on biotemplates

Advances in Tumor Targeting Biomimetic Drug Delivery Systems: A Promising Approach for Antitumor Therapy

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