Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
Jongkyun Kang,
Guodong Huang,
Long Ma
et al.
Abstract:Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease (PD), which is the leading neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). However, whether LRRK2 mutations cause PD and degeneration of DA neuronsviaa toxic gain-of-function or a loss-of-function mechanism is unresolved and has pivotal implications in LRRK2 based PD therapy. In this study, we investigate … Show more
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