Cell autonomous microglia defects in a stem cell model of frontotemporal dementia
Abhirami K. Iyer,
Lisa Vermunt,
Farzaneh S. Mirfakhar
et al.
Abstract:Neuronal dysfunction has been extensively studied as a central feature of neurodegenerative tauopathies. However, across neurodegenerative diseases, there is strong evidence for active involvement of immune cells like microglia in driving disease pathophysiology. Here, we demonstrate that tau mRNA and protein are expressed in microglia in human brains and in human induced pluripotent stem cell (iPSC)-derived microglia like cells (iMGLs). Using iMGLs harboring the MAPT IVS10+16 mutation and isogenic controls, w… Show more
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