Cell Autonomous Circadian Systems and Their Relation to Inflammation

Annamneedi, Venkata Prakash; Park, Jun Woo; Lee, Geum Seon; Kang, Tae Jin

doi:10.4062/biomolther.2020.215

Cited by 10 publications

(8 citation statements)

References 103 publications

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“…Immune functions such as leukocyte homing, and innate immunity responses also show circadian variations along with the components of immune system. Supporting the fact, it has been observed that IL-1 and IL-6 are only detectable during 12:00-3:00 am in the serum of healthy individuals [79]. Such rhythms have been equally seen in both males and females.…”

Section: Discussionmentioning

confidence: 69%

Circadian Liver Metabolism Affects Management of Type 2 Diabetes Mellitus During Cytokine Storm Due to COVID-19

Kumar

Jahan

2021

Chronobiol Med

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Diabetes is managed to keep the blood sugar in normal range. This involves liver as glucose metabolizing organ and sensitization of somatic cells to utilize this glucose for daily energy requirements. The management is subjected to the rhythmic glucose intake as diet and liver circadian cycles that runs parallel to this zeitgeber. COVID-19 patients having diabetes as comorbid condition face the challenges of inflammatory cytokine management along with the organization of glucose. Increased blood glucose level during the cytokine storm further aggravates the pathophysiology of COVID-19 patients leading to high morbidity and mortality in such patients. Clinical treatment of these patients requires multidimensional approach involving circadian variation of hepatic physiology, glucose intake, and inflammatory cytokine release.

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Section: Discussionmentioning

confidence: 69%

Circadian Liver Metabolism Affects Management of Type 2 Diabetes Mellitus During Cytokine Storm Due to COVID-19

Kumar

Jahan

2021

Chronobiol Med

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“… 33 Inflammatory factors could affect peripheral clock activity and the phase, period, and amplitude of expression of circadian clock genes in normal lung tissue were changed by exposure to cigarette smoke, viral or bacterial infection. 34 , 35 In addition, hormonal or autonomic nerve activity synchronized peripheral clocks to the suprachiasmatic nucleus rhythm and affect the asthma activity. 36 The aberrant hormone secretion or autonomic nerve activity might desynchronize peripheral clock rhythm and might affect the airway activity and allergic reaction.…”

Section: Discussionmentioning

confidence: 99%

“…36 Per2 gene regulates daily IL-1β production in macrophages and IFN-γ production in NK cells, altered Per2 gene thus leads to the impairment of immune function. 35 The majority of asthmatic patients have an allergy reaction and several studies showed the circadian disruption can promote allergy. 24,[37][38][39] The mechanism might relate to circadian gating of epithelial barrier function and immune responses that evolved to complex environmental physical, chemical, and biological stimulants and enhance host defense after exposure of stimulants.…”

Section: Discussionmentioning

confidence: 99%

Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma

Chen

Wang

et al. 2021

JAA

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Purpose Circadian clock is synchronized to the 24-hour day by the daily light–dark cycle and proper function of circadian rhythm is essential for many physiological processes. Disruption of circadian rhythm can affect disease processes and influence disease severity, treatment responses, and even survivorship. In this retrospective case-controlled study, we tried to explore whether expression of circadian clock genes was disturbed in patients with bronchial asthma. Patients and Methods We performed real-time quantitative reverse transcriptase-polymerase chain reactions to examine the expression of the nine core circadian clock genes ( BMAL1 , CK1ε , CLOCK , CRY1 , CRY2 , PER1 , PER2 , PER3 , and TIM ) in total leukocytes of peripheral blood collected at chest clinics from 120 patients with asthma and 60 health individuals. Results Expression levels of the nine circadian clock genes were significantly different between patients and healthy individuals, but not associated with the asthma control status. We also noted the difference of PER3 expression in asthmatic patients with and without nocturnal symptoms. In well-controlled asthmatics, expression of BMAL1 , CK1ε , CLOCK , CRY1 , CRY2 , and PER1 was significantly lower in patients with nocturnal symptoms than those without nocturnal symptoms. However, in not well-controlled asthmatics, expression of only BMAL1 , CK1ε , PER1 , and PER2 was significantly different between patients with and without nocturnal symptoms. Binary logistic regression analysis selected BMAL1 , CKIε , PER3 , and TIM as independent factors for bronchial asthma and ROC curves showed the combined expression of these four genes enhanced the capability of predicting asthma (AUC=0.924; 95% CI=0.875–0.958; P <0.001). Conclusion Our results showed altered expression of circadian clock genes in patients with bronchial asthma and down-regulated PER3 in patients with nocturnal symptoms. Altered expression of circadian clock genes was also observed in asthmatics with or without nocturnal symptoms in well- or not well-controlled subgroups. Combined expression of BMAL1 , CKIε , PER3 , and TIM could be a pot...

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“…Particularly, the production of the pro-inflammatory cytokines, including interleukin IL-6 and TNF-alpha, exhibit diurnal rhythmicity that correlates inversely with plasma cortisol [ 75 , 76 ]. Indeed, earlier studies on diurnal variation of cytokines reported that cytokine levels were highest in blood taken in the early morning or late evening [ 77 , 78 ]. In this study blood samples were collected between 8 a.m. and 5 p.m. as in the study by Kupper et [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Psychosomatic syndromes are associated with IL-6 pro-inflammatory cytokine in heart failure patients

et al. 2022

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Psychosomatic syndromes have emerged as an important source of comorbidity in cardiac patients and have been associated with increased risk for adverse outcomes in patients with heart failure (HF). Understanding of the mechanisms underlying this connection is limited, however immune activity represents a possible pathway. While there have been numerous studies connecting immune activity to psychosomatic psychopathology, there is a lack of research on patients with HF. We examined forty-one consecutive outpatients affected by HF. We assessed psychosomatic psychopathology using the Diagnostic Criteria for Psychosomatic Research (DCPR) and the Patient Health Questionnaire-15 (PHQ-15). The Psychosocial Index (PSI) was used for assessing stress and psychosocial dimensions. Depression was evaluated with Beck Depression Inventory-II (BDI-II). Circulating levels of proinflammatory cytokines IL-6 and TNF-alpha were ascertained. Univariate and multivariable regression models were used to test for associations between inflammatory cytokines and psychosomatic psychopathology (i.e., DCPR syndromes, PHQ-15) and psychological dimensions (i.e., BDI-II, PSI). A significant positive correlation was found between IL-6 levels and psychosomatic psychopathology even when controlling for any confounding variables (i.e., Body-mass index (BMI), New York Heart Association (NYHA) class, smoking habits, alcohol consumption, statin use, aspirin use, beta blockers use, age, and gender). In contrast, the associations between TNF-alpha levels were non-significant. These findings can contribute to research in support of a psychoneuroimmune connection between psychosomatic psychopathology and HF. Findings also suggest the possibility that elevated IL-6 levels are more relevant for the pathogenesis of psychosomatic syndromes than for depression in patients with HF.

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Cell Autonomous Circadian Systems and Their Relation to Inflammation

Cited by 10 publications

References 103 publications

Circadian Liver Metabolism Affects Management of Type 2 Diabetes Mellitus During Cytokine Storm Due to COVID-19

Circadian Liver Metabolism Affects Management of Type 2 Diabetes Mellitus During Cytokine Storm Due to COVID-19

Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma

Psychosomatic syndromes are associated with IL-6 pro-inflammatory cytokine in heart failure patients

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