Cell-Autonomous (Cell-Intrinsic) Stress Responses

Land, W.

doi:10.1007/978-3-319-78655-1_18

Cited by 3 publications

(2 citation statements)

References 232 publications

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“…However, the authors did not rule out the possibility that the microglia were undergoing functional changes (in cytokines) related to the inflammatory process. Nevertheless, neuronal changes observed in this SOD1G93A ALS model in the brain at 50 days of age were followed by microglial morphological changes at 60 days [105][106][107]. Therefore, the authors concluded that, if there is an inflammatory process in the retina, microglia would be in a different, less reactive or even neuroprotective phenotype [101].…”

Section: Summary Of Retinal Changes In Amyotrophic Lateral Sclerosis ...mentioning

confidence: 99%

“…Aforesaid, the induction of the different stages of CLD requires handling the animals for prolonged periods of time, which can affect and compromise animal welfare. On the other hand, we already know that stress influences affective behavior and stress hormone release may alter the pathophysiology of the CLD [105][106][107][108]. For this reason, the scientific community has been made aware of the importance of ensuring the socio-environmental welfare of experimental animals.…”

Section: Regulatory Issues Regarding the Use Of Animal Models In Cld ...mentioning

confidence: 99%

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Animal Models and Experimental Research in Medicine

2023

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Section: Summary Of Retinal Changes In Amyotrophic Lateral Sclerosis ...mentioning

confidence: 99%

Section: Regulatory Issues Regarding the Use Of Animal Models In Cld ...mentioning

confidence: 99%

Animal Models and Experimental Research in Medicine

2023

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Cell Death: a Molecular Perspective

et al. 2021

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Models of Hepatotoxicity for the Study of Chronic Liver Disease

Rodríguez‐Fragoso¹,

Rodríguez‐López²,

Sánchez-Quevedo³

2023

Animal Models and Experimental Research in Medicine

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Chronic liver disease affects globally and has a high morbidity and mortality rate. It is histopathologically characterized by the presence of inflammation, and the progressive destruction and regeneration of the hepatic parenchyma, which can lead to the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Most liver diseases tend to become chronic and can be therefore studied in animal models, as it is possible to quickly develop pathological processes in animals with a high degree of reproducibility and obtain predictive data regarding the different hepatopathies. The development of animal models in the field of hepatology has been geared toward the search for new knowledge meant to favor human well-being and proved useful in translational medicine focused on liver disease. Like any other methodological tool, animal models provide valuable. Obviously, a single model cannot reproduce the complexity and spectrum of all liver diseases, which is why a wide variety are currently employed: they include chemically, immune, diet, surgically, and genetically modified damage in animals and involve biological agents or the use of humanized livers in rodents. This chapter surveys some of the main animal models used in the study of chronic liver disease and the disease characteristics they mimic.

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Cell-Autonomous (Cell-Intrinsic) Stress Responses

Cited by 3 publications

References 232 publications

Animal Models and Experimental Research in Medicine

Animal Models and Experimental Research in Medicine

Cell Death: a Molecular Perspective

Models of Hepatotoxicity for the Study of Chronic Liver Disease

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