Cell and Bacteria-Baterial Interactions on the Ti10Mo8Nb Alloy After Surface Modification

Abstract

The purpose of this study is the surface modification of Ti10Mo8Nb experimental alloy by using TiO 2 nanostructure growth. Ingots of the Ti10Mo8Nb experimental alloy were produced by fusion from sheets of molybdenum, niobium, and titanium commercially pure in an arc melting furnace under argon atmosphere. The potentiostatic anodic oxidation was performed using an electrolyte formed of glycerol and H 2 O (1: 1 by vol.) with the addition of 2.7% (w/v) NH 4 F under 20 V for 3 h at room temperature. After the surface treatment, the samples were annealing. The surface of the alloy was analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), contact angle, surface energy measurements. In vitro studies, such as cell and bacterial adhesion, were performed to evaluate the response of this treatment. The Ti10Mo8Nb alloy exhibited beta phase after the processing. After the surface treatment, a nanoporous layer of TiO was obtained. The anatase phase was found in the annealed samples (450 ºC for 3 hours). In vitro analyzes showed cell growth viability and decreased bacterial proliferation due to the larger specific surface area.

Processing of the Ti25Ta25Nb3Sn Experimental Alloy Using ECAP Process for Biomedical Applications

“…These results have led to an increased interest in studies in this area. Some promising alloys developed recently include: Ti-Mo-Nb [4,7,8], Ti-Mo-Nb-Zr [3,9], Ti-Nb-Cu [10], Ti-Zr-Nb [11], Ti-Nb-Sn [12], Ti-Nb-Ta [13,14], Ti-Nb-Zr-Mn-Sn [15], Ti-Mo-Nb-O [16], Ti-Nb-Zr-Ta [16], Ti-Nb-Zr-Ta-Sn [1], and Ti-Ta-Nb-Sn [17,18].…”

Processing and Characterization of a New Quaternary Alloy Ti10Mo8Nb6Zr for Potential Biomedical Applications

“…Ti-Mo-Nb alloys have been evaluated as an option for biomedical applications [ 27 , 28 , 29 , 30 , 31 , 32 ]. The study of Ti 10 Mo 3 Nb, Ti 10 Mo 7 Nb, and Ti 10 Mo 10 Nb alloys indicated a microstructure with equiaxial grains, a beta-phase in the alpha-matrix, and an increase in the content of the beta-phase with the increase in the concentration of niobium in the composition.…”

“…In vitro studies showed strong adhesion, good proliferation, and cell differentiation results like those for CP Ti. The Ti-Mo-Nb system also showed no cytotoxicity or inflammatory response [ 30 , 32 ].…”

“…In general, zirconium and niobium favored a decrease in Young’s modulus and an increase in toughness and deformation. Therefore, our aim in the present study was to evaluate the influence of zirconium addition on the properties of the ternary system Ti 10 Mo 8 Nb previously evaluated by our group [ 31 , 32 , 43 ]. Mechanical and microstructural characterization was performed for the quaternary alloy Ti 10 Mo 8 Nb 6 Zr, and its potential for biomedical applications was evaluated.…”