Cell aggregation increases drug resistance of acute myeloid leukemia cells

Фадеев, Р. С.; Solovieva, Marina E.; Slyadovskiy, D A; Захаров, С Г; Фадеева, И. С.; Сенотов, А. С.; Dolgikh, Nadezda; Голенков, А. К.; Акатов, В. С.

doi:10.1134/s1990747815020063

Cited by 1 publication

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“…Furthermore, some mycotoxins, including 3-acetyldeoxynivalenol, beauvericin, brefeldin A, skyrin and T2 tetraol, stimulate the proliferation of THP-1 cells. The THP-1 cell line has been reported to be resistant to several drugs, and monocytic THP-1 human cell lines display different susceptibility to engineered nanoparticles compared to intestinal epithelial Caco-2 [ 36 , 37 ]. Caco-2 has also been found to be more sensitive to cyclopiazonic acids than THP-1 cells [ 38 ], which is consistent with our observations ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

In vitro screening of 65 mycotoxins for insecticidal potential

et al. 2021

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The economic losses and threats to human and animal health caused by insects and the pathogens transmitted by them require effective and environmentally-friendly methods of controlling them. One such group of natural biocontrol agents which may be used as biopesticides is that of the entomopathogenic fungi and their toxic secondary metabolites (mycotoxins). The present in vitro work examined the insecticidal potential of 65 commercially-available mycotoxins against the insect Sf-9 cell line. Mammalian Caco-2 and THP-1 cell lines served as reference controls to select insecticidal mycotoxins harmless to mammalian cells. All tested mycotoxins significantly reduced the in vitro proliferation of the Sf-9 cells and evoked morphological changes. Ten of the mycotoxins found to strongly inhibit Sf-9 proliferation also had moderate or no effect on Caco-2 cells. The THP-1 cells were highly resistant to the tested mycotoxins: doses 103 times higher were needed to affect viability and morphology (1 μg/ml for THP-1 versus 1 ng/ml for Sf-9 and Caco-2). Nine mycotoxins significantly decreased Sf-9 cell proliferation with minor effects on mammalian cells: cyclosporins B and D, cytochalasin E, gliotoxin, HC toxin, paxilline, penitrem A, stachybotrylactam and verruculogen. These may be good candidates for future biopesticide formulations.

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Section: Discussionmentioning

confidence: 99%