Abstract:During cell adhesion, integrins form clusters that transmit mechanical forces to the substrate (mechanotransduction) and regulate biochemical signaling depending on substrate stiffness. In recent years, mechanotransduction studies significantly advanced our understanding of cell adhesion. Most studies were performed on rigid substrates such as glass, while more physiologically relevant fluid membranes have been less explored. In contrast to rigid substrates, integrins' ligands on fluid supported lipid bilayers… Show more
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