Celiac disease, posterior cerebral calcifications and epilepsy

Gobbi, Giuseppe; Ambrosetto, Paolo; Zaniboni, M. G.; Lambertini, A.; Ambrosioni, G; Tassinari, C. A.

doi:10.1016/s0387-7604(12)80275-0

Cited by 35 publications

(23 citation statements)

References 20 publications

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“…Overall, the observed associations between GI problems and delayed milestones, CP and seizure disorders lend support to the idea that a sub-set of children with ASD might suffer from underlying neurological and/or immunological dysfunction that affects multiple organ systems and functions, including those that are GI related. They are also consistent with other studies showing associations between GI problems and epilepsy (Gobbi et al 1992) as well as the severity of CP (Erkin et al 2010).…”

Section: Discussionsupporting

confidence: 93%

Brief Report: Association Between Behavioral Features and Gastrointestinal Problems Among Children with Autism Spectrum Disorder

Maenner

Arneson

Levy

et al. 2011

J Autism Dev Disord

101

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Recent reports suggest certain behaviors among children with autism spectrum disorders (ASD) may indicate underlying gastro-intestinal (GI) problems, and that the presence of these behaviors may help alert primary care providers to the need to evaluate a child with ASD for GI problems. The purpose of this population-based study of 487 children with ASD, including 35 (7.2%) with a medically documented history of GI problems, was to compare behavioral features of children with and without a history of GI problems. Unusual sleeping or eating habits and oppositional behavior were significantly associated with GI problems. These behaviors, however, were frequent in both children with and without GI problems, suggesting they may have limited utility in a screening capacity for GI problems.

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Section: Discussionsupporting

confidence: 93%

Brief Report: Association Between Behavioral Features and Gastrointestinal Problems Among Children with Autism Spectrum Disorder

Maenner

Arneson

Levy

et al. 2011

J Autism Dev Disord

101

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“…29 In regard to mental retardation, both epilepsy with occipital brain calcifications and Down syndrome were previously reported in CD. 12,30,31 In contrast to these findings, the association between CD and autism is poor and probably does not exist. 32 Cerebellar ataxia has been well recognized in patients with CD, primarily in adults.…”

Section: Discussionmentioning

confidence: 68%

“…[3][4][5][6][7][8][9][10][11][12] Although earlier studies reported neurologic complications in patients with classical gluten enteropathy, some recent studies report neurologic disorders in asymptomatic CD patients. 13,14 Most of the patients who have CD and were reported as having neurologic manifestations were adults, and these manifestations were usually chronic and "hard," such as epilepsy, 12 cerebellar ataxia, 4,5,13,14 chronic neuropathies, 8,15 myoclonic ataxia, 9 progressive leukoencephalopathy, 7 and dementia. 16 The aim of this study was to screen for neurologic disorders in children and young adults who have CD and presented with either the classical infantile intestinal form or the milder late forms, including some asymptomatic patients.…”

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confidence: 99%

Range of Neurologic Disorders in Patients With Celiac Disease

et al. 2004

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ABSTRACT. Objective. During the past 2 decades, celiac disease (CD) has been recognized as a multisystem autoimmune disorder. A growing body of distinct neurologic conditions such as cerebellar ataxia, epilepsy, myoclonic ataxia, chronic neuropathies, and dementia have been reported, mainly in middle-aged adults. There still are insufficient data on the association of CD with various neurologic disorders in children, adolescents, and young adults, including more common and "soft" neurologic conditions, such as headache, learning disorders, attention-deficit/hyperactivity disorder (ADHD), and tic disorders. The aim of the present study is to look for a broader spectrum of neurologic disorders in CD patients, most of them children or young adults.Methods. Patients with CD were asked to fill in a questionnaire regarding the presence of neurologic disorders or symptoms. Their medical charts were reviewed, and those who were reported as having neurologic manifestations underwent neurologic examination and brain imaging or electroencephalogram if required. Their neurologic data were compared with that of a control group matched for age and gender.Results. Patients with CD were more prone to develop neurologic disorders (51.4%) in comparison with control subjects (19.9%). These disorders include hypotonia, developmental delay, learning disorders and ADHD, headache, and cerebellar ataxia. Epileptic disorders were only marginally more common in CD. In contrast, no difference was found in the prevalence of tic disorders in both groups. Therapeutic benefit, with gluten-free diet, was demonstrated only in patients with transient infantile hypotonia and migraine headache.Conclusion. This study suggests that the variability of neurologic disorders that occur in CD is broader than previously reported and includes "softer" and more common neurologic disorders, such as chronic headache, developmental delay, hypotonia, and learning disorders or ADHD. Future longitudinal prospective studies might better define the full range of these neurologic disorders and their clinical response to a gluten-free diet. Pediatrics 2004;113:1672-1676; celiac disease, neurologic disorders, migraine, attention-deficit/hyperactivity disorder, hypotonia.ABBREVIATIONS. CD, celiac disease; ADHD, attention-deficit/ hyperactivity disorder.A lthough in the past celiac disease (CD) was primarily considered to be a gluten enteropathy, during the past 2 decades, its clinical concept has been expanded, and it is now considered a multisystem autoimmune disorder, 1 with most of the patients being asymptomatic, oligosymptomatic, or present with extraintestinal manifestations. 2 Among these extraintestinal manifestations, there is a growing body of publications that report neurologic conditions that are associated with CD. 3-12 Although earlier studies reported neurologic complications in patients with classical gluten enteropathy, some recent studies report neurologic disorders in asymptomatic CD patients. 13,14 Most of the patients who have CD and were reported ...

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“…Two large studies of adults with celiac disease failed to detect an increased association [81,82]. The syndrome of occipital calcification, epilepsy in patients with celiac disease, may be reversed with a gluten-free diet [83][84][85].…”

Section: Neurologic Presentationsmentioning

confidence: 99%