Celiac disease in North Italian patients with autoimmune thyroid diseases

Spadaccino, A. C.; Basso, Daniela; Chiarelli, Silvia; Albergoni, Maria Paola; D’Odorico, Anna; Plebani, Mario; Pedini, B.; Lazzarotto, Francesca; Betterle, Corrado

doi:10.1080/08916930701620209

Cited by 50 publications

(36 citation statements)

References 22 publications

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“…However, there are a limited number of studies examining the prevalence of CD in children and adolescents with autoimmune thyroid disease. In studies conducted with adults, the prevalence of CD has been reported to be 10.8-3.3% in subjects with autoimmune thyroid disease (28)(29)(30). In studies conducted with children, the prevalence of CD has been reported to be 0.3-1.2% in healthy children and 1,3-6,5% in children and adolescents with a diagnosis of autoimmune thyroiditis (31,32).…”

Section: Discussionmentioning

confidence: 99%

Celiac disease in children and adolescents with Hashimoto Thyroiditis

et al. 2016

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Aim: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with Hashimoto thyroiditis (HT). Material and Methods:The data of a total of 80 patients with positive anti-thyroid antibodies who were aged between 6 and 17.9 years were retrospectively studied. Age, gender, complaints at the time of presentation, family history of thyroid disorders, clinical and laboratory findings were recorded. The levels of thyrotropin, free thyroxin, thyroid autoantibodies (thyroid peroxidase and thyroglobulin antibodies), immunoglobulin A (IgA), anti-tissue transglutaminase antibodies (IgA-tTG), and thyroid ultrasonography findings were enrolled.Results: Eighty patients (65 females (81.2%) and 15 males (18,8%)) were included in the study. Family history of thyroid disease was present in 38 (47.5%) patients. The most common complaints at the time of presentation were goiter (%30) and weight gain (%25). Forty three (53.8%), 23 (28.7%), and 14 (17.5%) patients presented with euthyroidism, subclinical hypothyroidism and obvious hypothyroidism. Thirty seven (46.2%) patients had goiter. IgA-tTG was found to be positive after a diagnosis of HT was made in only one patient (1.25%) and the diagnosis of CD was confirmed when intestinal biopsy of this patient revealed villus atrophy, crypt hyperplasia and increase in the intraepithelial lymphocyte count. Conclusions:In our study, it was found that the most common complaints at presentation in patients with a diagnosis of hashimoto thyroiditis included goiter, weakness and weight gain and the prevalence of celiac diseases was found to be 1.25% (1/80). This study shows that the prevalence of CD in patients with a diagnosis of HT is higher compared to the prevalence in the healthy pediatric population.

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Section: Discussionmentioning

confidence: 99%

Celiac disease in children and adolescents with Hashimoto Thyroiditis

et al. 2016

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“…(19), did not show a higher prevalence of CD in patients with hypothyroidism in an Iranian population, although their data disagree with those of various other authors (5,6,20).…”

Section: Discussionmentioning

confidence: 57%

Screening of celiac disease in patients with autoimmune thyroid disease from Southern Brazil

Teixeira

Nisihara

Utiyama

et al. 2014

Arq Bras Endocrinol Metab

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Objective: The objective of this study was to determine the prevalence of celiac disease (CD) in adults with autoimmune thyroid disease (ATD) from the endocrinology outpatient setting in a university hospital in Southern Brazil. Subjects and methods: From the years 2007 to 2011, 254 patients with ATD were enrolled consecutively, Grave's disease was diagnosed in 143 (56.3%) and Hashimoto's thyroiditis in 111 (43.7%) of them. All patients answered a questionnaire related to symptoms that could be associated with CD and serum samples to screen for IgA anti-endomysial (EmA-IgA) were collected. EmA-IgA-positive patients were offered upper gastrointestinal endoscopy and biopsy of duodenum. Results: A total of 254 patients were included; 222 (87.4%) female, mean age 45.4 ± 13.43 years (18 to 79 years). EmA-IgA was positive in seven patients (2.7%) and five done endoscopy with biopsy. Of these, three diagnosis of CD was confirmed (1.2%). All the three patients with CD had higher EmA-IgA titration, were female and had Hashimoto's thyroiditis. Like other patients with ATD, CD patients had nonspecific gastrointestinal symptoms, such as heartburn and gastric distention. In our study, one in each 85 patients confirmed the diagnosis of CD. Conclusion: We found a prevalence of 1.2% (1:85) of confirmed CD among Brazilian patients with ATD. Although some IgA-EmA positive patients had Graves' disease and one was male, all three patients with confirmed CD were female and had Hashimoto's thyroiditis.

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“…Thirdly, since we examined all patients with iron or vitamin B12 deficiency related anemia by gastroduodenoscopy, our observed prevalence of chronic atrophic gastritis and celiac disease may be higher than that reported in the literature. A study on North Italian patients with autoimmune thyroid disease also reported celiac disease (clinical, silent or latent) to be present in 5.4% of the patients (46). The associations between autoimmune thyroid diseases and allergic disorders have been studied in a lesser detail.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Autoimmune and Allergic Diseases with Autoimmune Thyroid Diseases

Duran¹,

Ağbaht²,

Soykan³

et al. 2017

Turk J Endocrinol Metab

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C Co oe ex xi is st te en nc ce e o of f A Au ut to oi im mm mu un ne e a an nd d A Al ll le er rg gi ic c D Di is se ea as se es s w wi it th h A Au ut to oi im mm mu un ne e T Th hy yr ro oi id d D Di is se ea as se es s O Ot to oi im mm mü ün n T Ti ir ro oi id d H Ha as st ta al lı ık kl la ar rı ıy yl la a B Bi ir rl li ik kt te e S Se ey yr re ed de en n O Ot to oi im mm mü ün n v ve e A Al ll le er rj ji ik k H Ha as st ta al lı ık kl la ar r Ankara University Faculty of Medicine, Department of Endocrinology and Metabolic Diseases, Ankara, Turkey *Ankara University Faculty of Medicine, Department of Gastroenterohepatology, Ankara, Turkey Background: Sometimes, the patients with autoimmune thyroiditis show certain symptoms despite having serum thyroid hormone levels within the desired range. In addition, the dose of levothyroxine replacement may vary in the patients with hypothyroidism. These factors directly inuence clinical practices and may, to some extent, be associated with other immunological/allergic diseases that accompany autoimmune thyroid diseases (ATDs). Purpose: To document the other autoimmune/allergic disorders in patients during follow-up for ATDs. Materials and Methods: During the study period, 274 patients diagnosed with, and/or at follow-up for Hashimoto's thyroiditis (HT), and 53 with Graves' disease (GD) were included in the study. All the patients were examined and were subjected to further investigations when the presence of other autoimmune/allergic diseases was suspected.Results: A total of 65 patients with HT (23.8%) and seven patients with GD (13.2%) had at least one additional clinical autoimmune/allergic disorder. Twentyeight (10.2%) patients with HT had gastrointestinal disorders (chronic atrophic gastritis and celiac disease), 19 (6.6%) had allergies (asthma, chronic urticaria, and rhinosinusitis), 12 (4.4%) had rheumatological disorders (rheumatoid arthritis), 10 (3.7%) had skin problems (vitiligo and psoriasis), four (1.5%) had endocrinological disorders (hypoparathyroidism, type-1 diabetes mellitus, and hypophysitis), one (0.4%) had hematological disease (idiopathic thrombocytopenic purpura), and one (0.4%) had renal disorder (crescentic glomerulonephritis). The prevalence patterns were similar in the patients with GD. In addition, 50 (18.2%) patients with HT and one (1.9%) with GD were observed to have vitamin B12 decient-anemia (p=0.001). Furthermore, 28 (10.2%) patients with HT and one (1.9%) with GD had dimorphic anemia (both vitamin B12 and iron deciencies). Discussion: The patients with ATDs are prone to additional autoimmune/allergic diseases, and it can be said that the patients with autoimmune thyroid diseases sometimes have more than just thyroid disease. The most involved organ system in both HT and GD is the gastrointestinal tract. This involvement probably plays a role in the exacerbation of some symptoms by causing anemia resulting from a deciency of both vitamin B12 and iron, especially in patients with HT.

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Celiac disease in North Italian patients with autoimmune thyroid diseases

Abstract: CD is significantly increased in patients with thyroid autoimmune disorders for this reason it is important to screen for CD in patients with AITDs.

Cited by 50 publications

References 22 publications

Celiac disease in children and adolescents with Hashimoto Thyroiditis

Celiac disease in children and adolescents with Hashimoto Thyroiditis

Screening of celiac disease in patients with autoimmune thyroid disease from Southern Brazil

Coexistence of Autoimmune and Allergic Diseases with Autoimmune Thyroid Diseases

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