Celiac disease in Iran: a systematic review and meta-analysis

Mohammadibakhsh, Roghayeh; Sohrabi, Rahim; Salemi, Morteza; Mirghaed, Masood Taheri; Behzadifar, Masoud

doi:10.19082/3883

Cited by 27 publications

(27 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Middle East where the western part of the Silk Roads runs through, the prevalence of coeliac disease has been documented 2,3 . In Turkey (1%‐1.74%), 4,5 Syria (1.67%) 6 and Iran (0.6%‐3%) 7,8 figures comparable to those reported in Europe and the United States were found. In the Han Chinese population living in the eastern part of the Silk Road, the seroprevalence of coeliac disease has been estimated to be only 0.06% 9 .…”

Section: Introductionmentioning

confidence: 69%

Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations

Zhou

Gao

et al. 2020

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Background: Epidemiological data of coeliac disease are lacking from the central Asian region. Aims: To verify the occurrence of coeliac disease amongst four major ethnic groups of Xinjiang Uyghur Autonomus Region, China. Methods: 2277 in-patients with gastrointestinal symptoms (1391 Han, 608 Uyghur, 146 Kazakh and 132 Hui; mean age: 54 ± 12.8 years) were included. Total IgA, antideamidated gliadin peptide (DGP)-IgG, and anti-tissue transglutaminase (anti-tTG)-IgA were analysed. All antibody-positive subjects were further tested for endomysial (EMA) antibodies and were HLA genotyped. All subjects with antibody positivity were asked to undergo intestinal biopsy. In addition, a subset of antibody-negative subjects were tested for HLA-DQA1and DQB1.Results: Among the 2277 subjects, 29 subjects were defined as coeliac disease autoimmune (positive results for anti-tTG IgA and EMA-IgA) (1.27%; 95% confidence interval, 0.81%-1.73%), eight of them underwent biopsy and all showed coeliac disease histology (0.35%; 95% Cl, 0.11%-0.59%). The frequency of coeliac disease autoimmunity was lowest among the Han (0.79%), followed by the Uyghur (1.81%), the Kazakh (2.05%) and the Hui (3.03%). The frequency of the HLA-DQ2 and/or DQ8 haplotype was highest in the Uyghur (52.1%), followed by the Hui (44.4%), the Kazakh (40.0%) and the Han (39.4%). Besides, a three times higher frequency of coeliac disease autoimmunity was found among rural living subjects with significantly higher wheat consumption compared to urban living subjects (3.16% vs 0.97%, P < 0.01). Conclusions:In Xinjiang, coeliac disease does occur, especially in the rural area. The HLA haplotype and environment play key roles in the development of coeliac disease. | 1117ZHOU et al.

show abstract

Section: Introductionmentioning

confidence: 69%

Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations

Zhou

Gao

et al. 2020

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Celiac disease (CD) is a common disorder that is caused by autoimmunity to the gluten protein. It affects about 0.7 to 1% of the population worldwide [1] and its prevalence in Iran is also similar to that of world-wide reported [2]. Eliminating Gluten-containing foods and products is the only effective management of celiac diseases [3].…”

Section: Introductionmentioning

confidence: 71%

Determinants of health-related quality of life in patients with celiac disease: a structural equation modeling

Nikniaz

Jafarabadi

Farhangi

et al. 2021

Preprint

View full text Add to dashboard Cite

Purpose We employed the structure equation modeling (SEM) for investigating the determinants of Helath-related quality of life (HRQOL) in Iranian patients with celiac disease (CD). Methods In the present cross-sectional study, a total of 170 patients with CD were recruited. The information regarding adherence to diet, symptom severity and HRQOL were collected using celiac disease adherence test (CDAT), gastrointestinal symptom rating scale (GSRS) and SF-36 questionnaire respectively. Association between various studied variables and HRQOL was assessed using SEM. The standardized regression weights was used to assess total, direct and indirect effects. The model fit was assessed to determine the “goodness of fit” between the hypothesized model. Results The mean age of participants was 37.57 ± 9.59 years. The results of SEM indicated that the overall fit of our model was acceptable. Adherence to the diet, GSRS score, occupation, and education level were significantly related to PCS of SF-36; and adherence to the diet, GSRS score, and education level were significantly correlated to MCS of SF-36. The analysis of indirect effect indicated that only adherence to diet indirectly via GSRS score was significantly associated with PCS and MCS of SF-36. There were significant differences between males and females regarding the relationship between education and adherence to diet (p<0.001) and education level and MCS of SF-36 (p=0.03). Conclusion In adult patients with celiac disease, HRQoL was affected by age, education level, adherence to GFD, and GSRS score. Additionally, occupation and disease duration were associated with HRQoL only in women and men respectively.

show abstract

“…When making a diagnosis of CD, it is very important to know if the patient suffers from the different symptoms; since studies that diagnose CD are invasive analyses [4,5,9,10,20,22,24,26,27,[30][31][32]37,39,41,43,45,46,[49][50][51]58]. Therefore, before requesting the analyses, it is useful to perform a Celiac Symptom Index test to identify the symptoms apart from the clear use of the clinical history; in this way, a better diagnosis can be made [57].…”

Section: Discussionmentioning

confidence: 99%

“…Flow diagram of the process of study selection.In 24 of the studies found, they used intestinal biopsy as the main source of diagnosis of celiac disease, followed by blood tests of immunoglobulin A, anti-inflammatory transglutaminase, and Immunoglobulin G[4,5,9,10,13,19,22,24,27,28,[30][31][32][39][40][41]43,45,46,[49][50][51].…”

mentioning

confidence: 99%

Tools Used to Measure the Physical State of Women with Celiac Disease: A Review with a Systematic Approach

Martínez-Rodríguez

Loaiza-Martínez

Sánchez-Sánchez

et al. 2020

IJERPH

View full text Add to dashboard Cite

Celiac disease (CD) is an immunological disorder that mainly affects the small intestine, generating an inflammatory process in response to the presence of gluten (a protein). Autoimmune diseases are part of a group of diseases that are difficult to diagnose without a specific protocol or consensus to detect them due to the number of symptoms and diseases with which it has a relationship. Therefore, the aim of this review was to analyze the diagnostic tools of CD used in middle-aged women, to compare the use and effectiveness of the different tools, and to propose a strategy for the use of the tools based on the results found in the literature. The present research followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The search was conducted in the following databases: Scielo, PubMed, Web of Science, and Worldwide Science org. In the initial literature search, 2004 titles and relevant abstracts were found. Among them, 687 were duplicates, leaving 1130 articles. Based on the inclusion criteria, only 41 articles passed the selection process; 4 main types of analyses appear in the studies: blood tests, questionnaires, clinical history, and biopsy. It can be said that none of the analyses have a 100% reliability since most of them can present false negatives; therefore, the best way to diagnose celiac disease up to now is through a combination of different tests (Immunoglobulin A and small intestinal biopsy).

show abstract

Celiac disease in Iran: a systematic review and meta-analysis

Cited by 27 publications

References 54 publications

Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations

Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations

Determinants of health-related quality of life in patients with celiac disease: a structural equation modeling

Tools Used to Measure the Physical State of Women with Celiac Disease: A Review with a Systematic Approach

Contact Info

Product

Resources

About